Oxidative stress reflected by elevated reactive oxygen species (ROS) in the tumor ecosystem, is a hallmark of human cancers. The mechanisms by which oxidative stress regulate the metastatic ecosystem and resistance remain elusive. This study aimed to dissect the oxidative stress-sensing machinery during the evolvement of early dissemination and acquired drug resistance in breast cancer.

中文翻译：

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RGS5+ 淋巴内皮细胞通过氧化应激感应机制促进乳腺癌的转移和获得性耐药


肿瘤生态系统中活性氧 （ROS） 升高所反映的氧化应激是人类癌症的标志。氧化应激调节转移性生态系统和耐药性的机制仍然难以捉摸。本研究旨在剖析乳腺癌早期播散和获得性耐药进化过程中的氧化应激感应机制。