Polyunsaturated fatty acids (PUFAs) play numerous roles in living organisms but are also prone to rapid aerobic oxidation, resulting in the production of a wide range of isomeric metabolites called oxylipins. Among these, isoprostanes, discovered in the 1990s, are formed non-enzymatically from ω–3 and ω–6 PUFAs with 16 to 22 carbon atoms. Over nearly 35 years of research, two nomenclature systems for isoprostanes have been proposed and have evolved. However, as research progresses, certain aspects of the current nomenclature remain unclear and require further clarification to ensure precise identification of each metabolite and its corresponding parent PUFA. Therefore, we propose an update to the current nomenclature system, along with practical guidelines for assessing isoprostanoid diversity and identifying their PUFA origins.

中文翻译：

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异前列烷类药物命名法的更新


多不饱和脂肪酸 （PUFA） 在生物体中发挥着多种作用，但也容易发生快速有氧氧化，从而产生多种称为氧磷脂的异构体代谢物。其中，1990 年代发现的异前列腺素是由具有 16 至 22 个碳原子的 ω-3 和 ω-6 多不饱和脂肪酸以非酶方式形成的。在近 35 年的研究中，已经提出并发展了两种异前列腺素命名系统。然而，随着研究的进展，当前命名法的某些方面仍不清楚，需要进一步澄清，以确保准确识别每种代谢物及其相应的母体 PUFA。因此，我们建议对当前的命名系统进行更新，以及评估异前列素多样性和确定其 PUFA 来源的实用指南。