Post-transplant recurrence of focal segmental glomerular sclerosis (FSGS) is a major challenge in the field of kidney transplantation. Currently, the most reliable predictor of FSGS recurrence is disease recurrence in a previous allograft. Recent studies suggest a possible causal role of anti-nephrin autoantibodies in the primary disease (primary FSGS and minimal change disease), as well as post-transplant recurrence of FSGS. In this issue of Kidney International, Batal et al. evaluate pretransplant anti-nephrin autoantibodies as a specific predictor of FSGS recurrence and demonstrate colocalization of nephrin and punctate IgG in anti-nephrin-positive patients with disease recurrence.

中文翻译：

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抗肾病蛋白自身抗体：局灶节段性肾小球硬化移植后复发的新预测因子。


局灶节段性肾小球硬化症（FSGS）的移植后复发是肾移植领域的主要挑战。目前，FSGS 复发最可靠的预测因素是先前同种异体移植物中的疾病复发。最近的研究表明，抗去氧肾上腺素自身抗体可能在原发性疾病（原发性 FSGS 和微小病变病）以及 FSGS 移植后复发中发挥因果作用。在本期《肾脏国际》中，Batal 等人。评估移植前抗去氧肾上腺素自身抗体作为 FSGS 复发的特异性预测因子，并证明去氧肾上腺素和点状 IgG 在疾病复发的抗去氧肾上腺素阳性患者中的共定位。