Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute kidney injury.

中文翻译：

---

西司他丁，一种治疗急性肾损伤的新疗法。


急性肾损伤是一种由多种原因引起的破坏性临床综合征，其特征是肾功能突然恶化，且无法进行药物治疗。西司他丁已在急性肾损伤中表现出直接的肾保护作用，现在被证明可以有效地将治疗负载的纳米颗粒特异性靶向近端肾小管，以治疗急性肾损伤。