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Lipid redistribution due to a cell-cell fusion pore
Biophysical Journal ( IF 3.2 ) Pub Date : 2024-09-18 , DOI: 10.1016/j.bpj.2024.09.015 David William Allender 1 , Michael Schick 2
Biophysical Journal ( IF 3.2 ) Pub Date : 2024-09-18 , DOI: 10.1016/j.bpj.2024.09.015 David William Allender 1 , Michael Schick 2
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We consider the redistribution of lipids comprising the plasma membranes during cell-cell fusion, particularly due to the presence of a fusion pore. Assuming the membranes are of constant thickness, we find that the mole fraction of cholesterol increases in the directly apposed exoplasmic leaflets, and is decreased in the cytoplasmic leaflets. The redistribution of the phospholipids is obtained as well.
中文翻译:
细胞间融合孔引起的脂质再分布
我们考虑了细胞间融合过程中构成质膜的脂质的重新分布,特别是由于融合孔的存在。假设膜的厚度恒定,我们发现胆固醇的摩尔分数在直接分配的外质小叶中增加,而在细胞质小叶中降低。磷脂的重新分布也是获得的。
更新日期:2024-09-18
中文翻译:
细胞间融合孔引起的脂质再分布
我们考虑了细胞间融合过程中构成质膜的脂质的重新分布,特别是由于融合孔的存在。假设膜的厚度恒定,我们发现胆固醇的摩尔分数在直接分配的外质小叶中增加,而在细胞质小叶中降低。磷脂的重新分布也是获得的。