We planned to assess iron overload in young transfusion-dependent thalassemia (TDT) patients with T2* MRI and correlate with serum ferritin. This study included young TDT patients aged 3 to 38 years on regular transfusion in a tertiary care facility from July 2017 to December 2018. T2* MRI was performed on all patients and correlated with serum ferritin values. Out of 193 cases over a period of one and half year, 26 (13.4%) cases showed mild, 48 (24.8%) moderate, and 92 (47.6%) cases showed severe hepatic iron overload. Cardiac iron overload detected none in 129, mild in 21, moderate in 12, severe in 31 patients. Pancreatic iron overload was observed none in 67, mild 35, moderate in 43, severe in 33 patients and could not be done in 15 patients. There is strong negative correlation between serum ferritin level and liver T2*. Moderate negative correlation of serum ferritin was found with cardiac T2*. Statistically significant difference was observed between pancreas iron overload and age group (P-value = 0.001). The results of this study are comparable with those of several earlier studies In addition, there is a significant correlation between serum ferritin levels and iron overload determined by T2* MRI data.

我们计划通过 T2* MRI 评估年轻的输血依赖性地中海贫血 (TDT) 患者的铁超负荷情况，并与血清铁蛋白相关联。这项研究纳入了 2017 年 7 月至 2018 年 12 月在三级医疗机构定期输血的 3 至 38 岁年轻 TDT 患者。对所有患者进行了 T2* MRI，并与血清铁蛋白值相关。在一年半期间的 193 例患者中，26 例（13.4%）为轻度肝铁超载，48 例（24.8%）为中度，92 例（47.6%）为重度肝铁超载。 129 名患者未检测到心脏铁超负荷，21 名患者为轻度，12 名患者为中度，31 名患者为重度。 67 例未观察到胰腺铁超负荷，35 例轻度，43 例中度，33 例重度，15 例无法进行。血清铁蛋白水平与肝脏T2*呈强负相关。血清铁蛋白与心脏 T2* 呈中度负相关。胰腺铁超负荷和年龄组之间观察到统计学显着差异（P 值 = 0.001）。这项研究的结果与几项早期研究的结果具有可比性。此外，血清铁蛋白水平与 T2* MRI 数据确定的铁超载之间存在显着相关性。