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Gut microbiota influence bladder tumour development
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2024-09-16 , DOI: 10.1038/s41585-024-00947-y Louise Lloyd
中文翻译:
肠道微生物群影响膀胱肿瘤的发展
更新日期:2024-09-16
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2024-09-16 , DOI: 10.1038/s41585-024-00947-y Louise Lloyd
New research, published in Nature, shows that gut microbiota carcinogen metabolism could contribute to chemical-induced carcinogenesis in the bladder.
Chronic exposure to N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) induces bladder cancer in mouse models. Thus, the investigators used this model to examine the influence of gut microbiota on BBN-induced carcinogenesis and toxicokinetics.
中文翻译:
肠道微生物群影响膀胱肿瘤的发展
发表在《自然》杂志上的新研究表明,肠道微生物群致癌物代谢可能导致化学诱导的膀胱癌发生。
长期暴露于N-丁基-N- (4-羟丁基)-亚硝胺 (BBN) 会在小鼠模型中诱发膀胱癌。因此,研究人员使用该模型来研究肠道微生物群对 BBN 诱导的致癌作用和毒代动力学的影响。