AimThis study aimed to investigate the association between the components of metabolic syndrome (MetS) and reproductive outcomes in women with polycystic ovary syndrome (PCOS) undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) embryo transfer cycle.MethodsThis is a retrospective study that included 720 women with PCOS from January 2018 to December 2021. Anthropometric, biochemical, and reproductive data of the study subjects were collected from electronic medical record. Women with PCOS met <3, 3, and >3 criteria of MetS were classified in group 1, 2, and 3, respectively.ResultsThe miscarriage rate in women with MetS was significantly higher than that in non‐MetS group (23.2% vs. 14.2%, p = 0.03). There was a significant increasing trend in miscarriage rate from group 1 to group 3 (p for trend <0.05). The miscarriage rate in group 3 was significantly higher than that in group 1 (29.3% vs. 14.2%, p < 0.05). Logistic regression analyses showed that women with at least four components of MetS (group 3) were independently associated with a high risk of miscarriage, with the odds ratios and 95% confidence intervals for group 2 and 3 versus group 1 were 1.38 (0.67–2.82) and 2.46 (1.06–5.74), respectively (p for trend = 0.04).ConclusionsPCOS women accompanied with at least four diagnostic criteria of MetS is independently associated with increased miscarriage rate when undergoing their first IVF or ICSI cycle.

中文翻译：

---

在接受体外受精或胞浆内单精子注射胚胎移植周期的多囊卵巢综合征女性中，流产率增加与至少四种代谢综合征相关


目的本研究旨在调查首次体外受精 (IVF) 或胞浆内单精子注射 (ICSI) 胚胎移植周期的多囊卵巢综合征 (PCOS) 女性的代谢综合征 (MetS) 组成部分与生殖结果之间的关联。一项回顾性研究，纳入了 2018 年 1 月至 2021 年 12 月期间 720 名患有 PCOS 的女性。研究对象的人体测量、生化和生殖数据是从电子病历中收集的。符合 MetS <3、3 和 >3 标准的 PCOS 女性分别分为第 1、2 和 3 组。结果 MetS 女性的流产率显着高于非 MetS 组（23.2% vs. 14.2%，p = 0.03）。从第 1 组到第 3 组，流产率呈显着增加趋势（p 趋势<0.05）。第 3 组的流产率显着高于第 1 组（29.3% vs. 14.2%，p < 0.05）。 Logistic 回归分析显示，至少具有四种 MetS 成分的女性（第 3 组）与流产高风险独立相关，第 2 组和第 3 组与第 1 组相比，比值比和 95% 置信区间为 1.38（0.67-2.82） ) 和 2.46 (1.06–5.74)（趋势 p = 0.04）。 结论 具有至少 4 项 MetS 诊断标准的 PCOS 女性在接受第一个 IVF 或 ICSI 周期时与流产率增加独立相关。