Metabolic rewiring of a population of tumour-associated macrophages facilitates progression of glioblastoma, new research has revealed. A multi-omics approach demonstrated that the macrophages develop a lipid-laden phenotype, in which they accumulate cholesterol after uptake of myelin debris. Transfer of this accumulated cholesterol to glioblastoma cells helps to meet the high metabolic requirements of the tumour and sustain its growth. These mechanistic insights provide an opportunity for therapeutic targeting of lipid-laden macrophages.

中文翻译：

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被劫持的巨噬细胞维持胶质母细胞瘤细胞

新的研究表明，肿瘤相关巨噬细胞群的代谢重新布线促进了胶质母细胞瘤的进展。多组学方法表明，巨噬细胞发展出一种富含脂质的表型，其中它们在摄取髓鞘碎片后积累胆固醇。将这种积累的胆固醇转移到胶质母细胞瘤细胞有助于满足肿瘤的高代谢需求并维持其生长。这些机制见解为治疗靶向富含脂质的巨噬细胞提供了机会。