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HIV incidence among non-migrating persons following a household migration event in Uganda.
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2024-08-14 , DOI: 10.1093/ije/dyae118 Ruth Young 1 , Joseph Ssekasanvu 2 , Joseph Kagaayi 3 , Robert Ssekubugu 3 , Godfrey Kigozi 3 , Steven J Reynolds 4, 5 , Maria J Wawer 2, 3, 6 , Bareng Aletta Sanny Nonyane 1 , Betty Nantume 2 , Thomas C Quinn 4, 5 , Aaron A R Tobian 2, 4, 7 , John Santelli 8 , Larry W Chang 2, 4 , Caitlin E Kennedy 1 , Ligia Paina 1 , Philip A Anglewicz 6 , David Serwadda 9 , Fred Nalugoda 3 , Mary Kate Grabowski 2, 7
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2024-08-14 , DOI: 10.1093/ije/dyae118 Ruth Young 1 , Joseph Ssekasanvu 2 , Joseph Kagaayi 3 , Robert Ssekubugu 3 , Godfrey Kigozi 3 , Steven J Reynolds 4, 5 , Maria J Wawer 2, 3, 6 , Bareng Aletta Sanny Nonyane 1 , Betty Nantume 2 , Thomas C Quinn 4, 5 , Aaron A R Tobian 2, 4, 7 , John Santelli 8 , Larry W Chang 2, 4 , Caitlin E Kennedy 1 , Ligia Paina 1 , Philip A Anglewicz 6 , David Serwadda 9 , Fred Nalugoda 3 , Mary Kate Grabowski 2, 7
Affiliation
BACKGROUND
The impact of migration on HIV risk among non-migrating household members is poorly understood. We measured HIV incidence among non-migrants living in households with and without migrants in Uganda.
METHODS
We used four survey rounds of data collected from July 2011 to May 2018 from non-migrant participants aged 15-49 years in the Rakai Community Cohort Study. Non-migrants were individuals with no-migration between surveys or at the prior survey. Household migration was defined as ≥1 household member migrating into or out of the house from another community between surveys (∼18 months). Incident HIV was defined as testing HIV seropositive following a negative result. Incidence rate ratios (IRRs) were estimated using Poisson regression with generalized estimating equations. Analyses were stratified by gender, migration into or out of the household and the relationship between non-migrants and migrants (e.g. spouse, child).
RESULTS
About 11 318 non-migrants (5674 women) were followed for 37 320 person-years. Twenty-eight percent (6059/21 370) of non-migrant person-visits had recent migration into or out of the household, and 240 HIV incident cases were identified. Overall, non-migrants in migrant households were not at greater risk of acquiring HIV than non-migrants in households without any migration. However, men were significantly more likely to acquire HIV if their spouse had recently migrated in [adjusted IRR: 2.12; 95% confidence interval (CI): 1.05-4.27] or out (adjusted IRR: 4.01; 95% CI, 2.16-7.44) compared with men with no spousal migration.
CONCLUSIONS
HIV incidence is higher among non-migrant men with migrant spouses. Targeted HIV testing and prevention interventions like pre-exposure prophylaxis could be considered for men with migrant spouses.
中文翻译:
乌干达家庭移徙事件后非移徙者的艾滋病毒发病率。
背景 人们对移民对非移民家庭成员艾滋病毒风险的影响知之甚少。我们测量了乌干达有移民和无移民家庭中非移民的艾滋病毒感染率。方法 我们使用了 2011 年 7 月至 2018 年 5 月从 Rakai 社区队列研究中 15-49 岁非移民参与者收集的四轮数据。非移民是指两次调查之间或上次调查时没有移民的个人。家庭迁移被定义为在调查期间(约18个月)有≥1名家庭成员从另一个社区迁入或迁出房屋。 HIV事件被定义为阴性结果后检测HIV血清呈阳性。使用具有广义估计方程的泊松回归来估计发病率比(IRR)。分析按性别、移入或移出家庭以及非移徙者与移徙者(例如配偶、子女)之间的关系进行分层。结果 约 11 318 名非移民(5674 名女性)接受了为期 37 320 人年的随访。 28% (6059/21 370) 的非移民访问者最近迁入或迁出家庭,并发现了 240 起艾滋病毒病例。总体而言,流动家庭中的非流动人口感染艾滋病毒的风险并不比没有任何流动人口的家庭中的非流动人口更大。然而,如果男性的配偶最近移民到[调整后的内部收益率:2.12;与没有配偶移民的男性相比,95% 置信区间 (CI):1.05-4.27] 或超出(调整后 IRR:4.01;95% CI,2.16-7.44)。结论 配偶为流动人口的非流动男性的艾滋病毒感染率较高。对于配偶为移民的男性,可以考虑进行有针对性的艾滋病毒检测和预防干预措施,例如暴露前预防。
更新日期:2024-08-14
中文翻译:
乌干达家庭移徙事件后非移徙者的艾滋病毒发病率。
背景 人们对移民对非移民家庭成员艾滋病毒风险的影响知之甚少。我们测量了乌干达有移民和无移民家庭中非移民的艾滋病毒感染率。方法 我们使用了 2011 年 7 月至 2018 年 5 月从 Rakai 社区队列研究中 15-49 岁非移民参与者收集的四轮数据。非移民是指两次调查之间或上次调查时没有移民的个人。家庭迁移被定义为在调查期间(约18个月)有≥1名家庭成员从另一个社区迁入或迁出房屋。 HIV事件被定义为阴性结果后检测HIV血清呈阳性。使用具有广义估计方程的泊松回归来估计发病率比(IRR)。分析按性别、移入或移出家庭以及非移徙者与移徙者(例如配偶、子女)之间的关系进行分层。结果 约 11 318 名非移民(5674 名女性)接受了为期 37 320 人年的随访。 28% (6059/21 370) 的非移民访问者最近迁入或迁出家庭,并发现了 240 起艾滋病毒病例。总体而言,流动家庭中的非流动人口感染艾滋病毒的风险并不比没有任何流动人口的家庭中的非流动人口更大。然而,如果男性的配偶最近移民到[调整后的内部收益率:2.12;与没有配偶移民的男性相比,95% 置信区间 (CI):1.05-4.27] 或超出(调整后 IRR:4.01;95% CI,2.16-7.44)。结论 配偶为流动人口的非流动男性的艾滋病毒感染率较高。对于配偶为移民的男性,可以考虑进行有针对性的艾滋病毒检测和预防干预措施,例如暴露前预防。