Early Biological Therapy Within 12 Months of Diagnosis Leads to Higher Transmural Healing Rates in Crohn’s Disease,Clinical Gastroenterology and Hepatology

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Early Biological Therapy Within 12 Months of Diagnosis Leads to Higher Transmural Healing Rates in Crohn’s Disease
Clinical Gastroenterology and Hepatology ( IF 11.6 ) Pub Date : 2024-08-30 , DOI: 10.1016/j.cgh.2024.07.034
Joana Revés ₁ , Agnes Fernandez-Clotet ₂ , Ingrid Ordás ₂ , Anthony Buisson ₃ , Maëva Bazoge ₃ , Constance Hordonneau ₄ , Pierre Ellul ₅ , Melvin D'Anastasi ₆ , Ainara Elorza ₇ , Marta Aduna ₈ , Iago Rodríguez-Lago ₇ , Inês Sousa Lajas ₉ , Ana Raimundo ₉ , Paulo J G Bettencourt ₁₀ , Gonçalo Freire ₁₁ , Pedro Sousa ₁₁ , Ana Primitivo ₁₁ , Ivo Delgado ₁₁ , Jordi Rimola ₁₂ , Joana Torres ₁₃

Affiliation

Hospital Beatriz Ângelo, Gastroenterology Department, Loures, Portugal.
Hospital Clínic de Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS- and CIBEREHD, IBD Unit, Department of Gastroenterology, Barcelona, Spain.
Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, 3iHP, Service d'Hépato-Gastro Entérologie, Clermont-Ferrand, France; Université Clermont Auvergne, 3iHP, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, France.
Université Clermont Auvergne, Service de Radiologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Mater Dei Hospital, University of Malta, Division of Gastroenterology, Msida, Malta.
Mater Dei Hospital, University of Malta, Medical Imaging Department, Msida, Malta.
Hospital Universitario de Galdakao, Department of Gastroenterology; Biobizkaia Health Research Institute, Galdakao, Spain.
OSATEK-Hospital Universitario de Galdakao, Department of Radiology, Galdakao, Spain.
Universidade Católica Portuguesa, Faculty of Medicine, Rio de Mouro, Portugal.
Universidade Católica Portuguesa, Faculty of Medicine, Rio de Mouro, Portugal; Universidade Católica Portuguesa, Centre for Interdisciplinary Research in Health, Lisbon, Portugal.
Hospital Beatriz Ângelo, Department of Radiology, Loures, Portugal.
Hospital Clínic de Barcelona- IDIBAPS, Department of Radiology, Barcelona, Spain.
Hospital Beatriz Ângelo, Gastroenterology Department, Loures, Portugal; University of Lisbon, Faculty of Medicine, Lisbon, Portugal; Hospital da Luz de Lisboa, Gastroenterology Department, Lisbon, Portugal.

Transmural healing (TH) is emerging as a potential Crohn's disease (CD) treatment target. Early biological treatment seems to be associated with improved disease outcomes, but its impact on TH remains unclear. We aimed to assess the impact of early biological treatment initiation on TH and its influence on CD prognosis.

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