Key Message

Synthetic cannabinoids are an increasingly widespread drug of concern. Given their toxicity and newfound ubiquity, psychiatrists need to be able to manage their adverse effects. They have been linked to exacerbation of certain psychiatric conditions, and we highlight a unique case where neuroleptic malignant syndrome was associated with this.

Learning Points

1. All patients who require antipsychotics should be screened for concurrent synthetic cannabinoid use, given the propensity of these illicit substances to precipitate muscle injury, kidney damage, and potentially NMS.
2. If both are present, antipsychotics should be discontinued in favor of benzodiazepines and other non anti-dopaminergic medications.
3. Usage of restraints should also be minimized to reduce further exacerbations of muscle injury.

 关键信息

合成大麻素是一种日益受到广泛关注的药物。鉴于它们的毒性和新发现的普遍性，精神科医生需要能够控制它们的不良影响。它们与某些精神疾病的恶化有关，我们重点介绍了一个与此相关的抗精神病药物恶性综合征的独特病例。

 学习要点

1. 
   考虑到这些非法物质容易导致肌肉损伤、肾脏损伤和潜在的 NMS，所有需要抗精神病药物的患者都应该接受是否同时使用合成大麻素的筛查。
2. 
   如果两者都存在，则应停用抗精神病药物，转而使用苯二氮卓类药物和其他非抗多巴胺能药物。
3. 
   还应尽量减少使用约束装置，以减少肌肉损伤的进一步恶化。