BACKGROUND It has been reported that patients with geriatric psychiatric disorders include many cases of the prodromal stages of neurodegenerative diseases. Abnormal 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane dopamine transporter single-photon emission computed tomography (DAT-SPECT) reveals a nigrostriatal dopaminergic deficit and is considered useful to detect dementia with Lewy bodies and Parkinson's disease as well as progressive supranuclear palsy and corticobasal degeneration. We aimed to determine the proportion of cases that are abnormal on DAT-SPECT in patients with geriatric psychiatric disorders and to identify their clinical profile. METHODS The design is a cross-sectional study. Clinical findings of 61 inpatients aged 60 years or older who underwent DAT-SPECT and had been diagnosed with psychiatric disorders, but not neurodegenerative disease or dementia were analysed. RESULTS 36 of 61 (59%) had abnormal results on DAT-SPECT. 54 of 61 patients who had DAT-SPECT (89%) had undergone 123I-metaiodobenzylguanidine myocardial scintigraphy (123I-MIBG scintigraphy); 12 of the 54 patients (22.2%) had abnormal findings on 123I-MIBG scintigraphy. There were no cases that were normal on DAT-SPECT and abnormal on 123I-MIBG scintigraphy. DAT-SPECT abnormalities were more frequent in patients with late-onset (55 years and older) psychiatric disorders (69.0%) and depressive disorder (75.7%), especially late-onset depressive disorder (79.3%). CONCLUSION Patients with geriatric psychiatric disorders include many cases showing abnormalities on DAT-SPECT. It is suggested that these cases are at high risk of developing neurodegenerative diseases characterised by a dopaminergic deficit. It is possible that patients with geriatric psychiatric disorders with abnormal findings on DAT-SPECT tend to show abnormalities on DAT-SPECT first rather than on 123I-MIBG scintigraphy.

中文翻译：

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DAT-SPECT 揭示老年精神疾病患者潜在的多巴胺能缺陷：一项横断面研究。


背景技术据报道，患有老年精神疾病的患者包括许多处于神经退行性疾病前驱阶段的病例。异常 123I-2β-甲甲氧基-3β-(4-碘苯基)-N-(3-氟丙基)去甲托烷多巴胺转运蛋白单光子发射计算机断层扫描 (DAT-SPECT) 显示黑质纹状体多巴胺能缺陷，被认为有助于检测路易痴呆症身体和帕金森病以及进行性核上性麻痹和皮质基底节变性。我们的目的是确定老年精神疾病患者中 DAT-SPECT 异常的病例比例，并确定其临床特征。方法 该设计是一项横断面研究。对 61 名 60 岁或以上住院患者的临床结果进行了分析，这些患者接受了 DAT-SPECT，并被诊断为精神疾病，但未诊断为神经退行性疾病或痴呆。结果 61 人中有 36 人 (59%) DAT-SPECT 结果异常。 61 名接受 DAT-SPECT 的患者中，有 54 名（89%）接受过 123I-间碘苄基胍心肌闪烁扫描（123I-MIBG 闪烁扫描）； 54 名患者中有 12 名 (22.2%) 在 123I-MIBG 闪烁扫描中有异常发现。无DAT-SPECT正常和123I-MIBG闪烁扫描异常的病例。 DAT-SPECT 异常在晚发性（55 岁及以上）精神疾病 (69.0%) 和抑郁症 (75.7%) 患者中更为常见，尤其是晚发性抑郁症 (79.3%)。结论 老年精神疾病患者中许多病例在 DAT-SPECT 上显示异常。研究表明，这些病例罹患以多巴胺能缺陷为特征的神经退行性疾病的风险很高。 DAT-SPECT 发现异常的老年精神疾病患者可能首先在 DAT-SPECT 上显示异常，而不是在 123I-MIBG 闪烁扫描上显示异常。