Objectives Patients with rheumatoid arthritis (RA) have substantially elevated risk for cardiovascular diseases, and low cardiorespiratory fitness (VO2max) is a major mediator. The aim of this assessor-blinded, two-armed multicentre randomised controlled trial was to evaluate the effects of high-intensity interval training (HIIT) and strength exercise on cardiovascular health, physical fitness and overall health in patients with RA. Methods In total, 87 patients (86% female; aged 20–60 years) were randomly assigned to an intervention group (IG) or a control group (CG). The IG performed HIIT and strength exercise for 12 weeks. The CG was instructed to be physically active on a moderately intensive level, ≥150 min/week. Primary outcome was change in VO2max. Secondary outcomes were changes in anthropometry measures, muscle strength, overall health (Visual Analogue Scale (VAS)-Global), Patient Global Impression of Change (PGIC), pain and disease activity (Disease Activity Score in 28 joints (DAS28)). Results There was a significant mean group difference of change on VO2max (3.71 mL/kg/min; 95% CI 2.16, 5.25) in favour of the IG. Significant mean group differences of change were also seen for O2-pulse (1.38; 95% CI 0.85 to 1.91), waist circumference (−2.6; 95% CI −5.09 to –0.18), 1-minute sit-to-stand (5.0; 95% CI 3.35 to 6.72), handgrip strength (28.5; 95% CI 3.80 to 52.8), overall health (−14.7; 95% CI –23.8 to –5.50) and PGIC (p<0.0001) in favour of the IG. No significant mean group differences of change were found for pain (−4.0; 95% CI −13.07 to 5.06), DAS28 (−0.25; 95% CI −0.60 to 0.10) and erythrocyte sedimentation rate (−0.64; 95% CI −3.23 to 1.90). Conclusion Supervised HIIT and strength exercise improved cardiovascular health, physical fitness and overall health without a deterioration in pain and disease activity and should be considered in patients with well-controlled RA. Trial registration number [NCT05768165][1]. Data are available upon reasonable request. The dataset analysed in the present study are available from the corresponding author on reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05768165&atom=%2Fbjsports%2F58%2F23%2F1409.atom

中文翻译：

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高强度间歇训练可改善类风湿性关节炎患者的心血管和身体健康：一项多中心随机对照试验


目的 类风湿性关节炎 （RA） 患者发生心血管疾病的风险显著升高，心肺适能低 （VO2max） 是主要的中介因素。这项评估者设盲的双臂多中心随机对照试验的目的是评估高强度间歇训练 （HIIT） 和力量锻炼对 RA 患者心血管健康、身体健康和整体健康的影响。方法 总共 87 例患者 （86% 为女性;年龄 20-60 岁） 被随机分配到干预组 （IG） 或对照组 （CG）。IG 进行了 12 周的 HIIT 和力量锻炼。CG 被指示进行中等强度的身体活动，每周 ≥150 分钟。主要结局是 VO2max 的变化。次要结局是人体测量、肌肉力量、整体健康状况 （视觉模拟量表 （VAS）-Global）、患者整体印象变化 （PGIC） 、疼痛和疾病活动 （28 个关节疾病活动评分 （DAS28）） 的变化。结果 VO2max 变化的平均组差异显著 （3.71 mL/kg/min;95% CI 2.16， 5.25） 有利于 IG。O2 脉搏 （1.38;95% CI 0.85 至 1.91）、腰围 （-2.6;95% CI -5.09 至 -0.18）、1 分钟坐姿-站姿 （5.0;95% CI 3.35 至 6.72）、握力 （28.5;95% CI 3.80 至 52.8）、总体健康状况 （-14.7;95% CI -23.8 至 -5.50） 和 PGIC （p<0.0001） 也观察到显著的平均组变化差异，有利于 IG。在疼痛（-4.0;95% CI -13.07 至 5.06）、DAS28（-0.25;95% CI -0.60 至 0.10）和红细胞沉降率（-0.64;95% CI -3.23 至 1.90）方面未发现显著的平均组变化差异。 结论 有监督的 HIIT 和力量运动改善了心血管健康、体能和整体健康状况，而疼痛和疾病活动没有恶化，应考虑用于控制良好的 RA 患者。试验注册号 [NCT05768165][1]。数据可根据合理要求提供。本研究中分析的数据集可应合理要求从通讯作者处获得。[1]： /lookup/external-ref？link_type=CLINTRIALGOV&access_num=NCT05768165&atom=%2Fbjsports%2F58%2F23%2F1409.原子