BACKGROUND Subtypes of sinusitis have different symptoms and prognoses due to different pathogens. Odontogenic maxillary sinusitis (OMS) mainly occurs unilaterally and is different from chronic rhinosinusitis (CRS) usually occurring bilaterally in terms of clinical characteristics. However, comprehensive microbiological comparisons between OMS and CRS have never been systematically conducted and most comparisons are methodologically biased. This study aims to provide a comprehensive analysis of the microbiology associated with OMS and CRS through a meta-analysis approach in order to provide evidence for differential diagnosis of OMS and CRS from a microbiological perspective. METHODS The databases PubMed and CNKI were searched from their inception to July 2023. A random-effects model was employed to derive the pooled prevalence estimates of the identified bacterial species or genera. RESULTS The 17 represented studies included 6 concerning OMS, 12 concerning CRS, and 4 concerning normal sinus, yielding 191, 610, and 92 samples, respectively. Though not statistically significant, the prevalence of Peptostreptococcus and Prevotella was generally higher in OMS compared to CRS. Notably, Fusobacterium was identified as the only genus with a significantly higher prevalence in OMS compared to CRS. CONCLUSION Fusobacterium was significantly more prevalent in OMS compared with CRS, while Staphylococcus aureus was more prevalent in CRS than in OMS. Such differences in bacterial profile may partly explain the distinct pathology observed and contribute to the development of novel strategies for diagnosis and therapeutic interventions in OMS.

中文翻译：

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牙源性上颌窦炎微生物学与慢性鼻窦炎的比较：荟萃分析。


背景技术鼻窦炎的不同亚型因病原体不同而有不同的症状和预后。牙源性上颌窦炎（OMS）主要发生在单侧，与通常发生在双侧的慢性鼻窦炎（CRS）在临床特征上有所不同。然而，OMS 和 CRS 之间的全面微生物学比较从未系统地进行过，并且大多数比较在方法上存在偏差。本研究旨在通过荟萃分析方法对OMS和CRS相关的微生物学进行全面分析，为从微生物学角度鉴别诊断OMS和CRS提供证据。方法 检索 PubMed 和 CNKI 数据库从建库到 2023 年 7 月的数据。采用随机效应模型得出已识别细菌种或属的汇总流行率估计值。结果 17 项代表性研究包括 6 项有关 OMS、12 项有关 CRS 和 4 项有关正常窦，分别产生 191、610 和 92 个样本。尽管没有统计学意义，但与 CRS 相比，OMS 中消化链球菌和普氏菌的患病率普遍较高。值得注意的是，梭杆菌属被认为是唯一一个在 OMS 中患病率显着高于 CRS 的属。结论 与 CRS 相比，OMS 中梭杆菌明显更常见，而 CRS 中金黄色葡萄球菌比 OMS 中更常见。细菌谱的这种差异可能部分解释了观察到的不同病理学，并有助于开发 OMS 诊断和治疗干预的新策略。