BACKGROUND Hypersexuality (HS) accompanying neurological conditions remains poorly characterized despite profound psychosocial impacts. Objective We aimed to systematically review the literature on HS in patients with neurological disorders. Study selection and analysis We conducted a systematic review to identify studies that reported HS in neurological disorders. HS was defined as a condition characterized by excessive and persistent preoccupation with sexual thoughts, urges, and behaviors that cause significant distress or impairment in personal, social, or occupational functioning. Data on demographics, assessment techniques, associated elements, phenotypic manifestations, and management strategies were also extracted. Findings The final analysis included 79 studies on HS, encompassing 32 662 patients across 81 cohorts with neurological disorders. Parkinson's disease was the most frequently studied condition (55.6%), followed by various types of dementia (12.7%). Questionnaires were the most common assessment approach for evaluating HS, although the techniques varied substantially. Alterations in the dopaminergic pathways have emerged as contributing mechanisms based on the effects of medication cessation. However, standardized treatment protocols still need to be improved, with significant heterogeneity in documented approaches. Critical deficiencies include risks of selection bias in participant sampling, uncontrolled residual confounding factors, and lack of blinded evaluations of reported outcomes. Conclusions and clinical implications Despite growth in the last decade, research on HS remains limited across neurological conditions, with lingering quality and methodological standardization deficits. Key priorities include advancing assessment tools, elucidating the underlying neurobiology, and formulating management guidelines. PROSPERO REGISTRATION NUMBER CRD42017036478.

中文翻译：

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神经系统疾病中的性欲亢进：系统评价。


背景尽管对社会心理产生了深远的影响，但伴随神经系统疾病的性欲亢进（HS）的特征仍然很少。目的 我们旨在系统回顾有关神经系统疾病患者 HS 的文献。研究选择和分析 我们进行了系统回顾，以确定报告神经系统疾病中的 HS 的研究。 HS被定义为一种以过度且持续地关注性思想、性冲动和行为为特征的病症，这些病症会导致个人、社交或职业功能的显着痛苦或损害。还提取了人口统计、评估技术、相关要素、表型表现和管理策略的数据。结果 最终分析包括 79 项 HS 研究，涵盖 81 个患有神经系统疾病的队列中的 32 662 名患者。帕金森病是最常研究的疾病（55.6%），其次是各种类型的痴呆症（12.7%）。尽管技术差异很大，但调查问卷是评估 HS 的最常见评估方法。多巴胺能通路的改变已成为基于停药影响的贡献机制。然而，标准化治疗方案仍需要改进，记录的方法存在显着的异质性。关键缺陷包括参与者抽样中的选择偏差风险、不受控制的残留混杂因素以及缺乏对报告结果的盲法评估。结论和临床意义 尽管过去十年有所增长，但针对神经系统疾病的 HS 研究仍然有限，质量和方法标准化缺陷挥之不去。 关键优先事项包括改进评估工具、阐明潜在的神经生物学以及制定管理指南。普洛斯彼罗注册号 CRD42017036478。