Absence of Glucocorticoids Concomitant With Avacopan and Subsequent Liver Injury in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.,The Journal of Rheumatology

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Absence of Glucocorticoids Concomitant With Avacopan and Subsequent Liver Injury in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
The Journal of Rheumatology ( IF 3.6 ) Pub Date : 2024-08-15 , DOI: 10.3899/jrheum.2024-0340
Tomohisa Uchida ₁ , Shoichi Fukui ₂ , Naoki Iwamoto ₃ , Ayaka Umetsu ₄ , Momoko Okamoto ₅ , Keita Fujikawa ₆ , Akinari Mizokami ₇ , Takuya Tomokawa ₈ , Kazusato Hara ₉ , Yoshiro Horai ₁₀ , Atsushi Kawakami ₁₁

Affiliation

Tomohisa Uchida, MD, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki.
Shoichi Fukui, MD, PhD, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki.
Naoki Iwamoto, MD, PhD, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki.
Ayaka Umetsu, MD, Department of Rheumatology, Japan Community Healthcare Organization (JCHO) Isahaya General Hospital, Isahaya.
Momoko Okamoto, MD, PhD, Department of Rheumatology, Japan Community Healthcare Organization (JCHO) Isahaya General Hospital, Isahaya.
Keita Fujikawa, MD, PhD, Department of Rheumatology, Japan Community Healthcare Organization (JCHO) Isahaya General Hospital, Isahaya.
Akinari Mizokami, MD, PhD, Department of Rheumatology, Japan Community Healthcare Organization (JCHO) Isahaya General Hospital, Isahaya.
Takuya Tomokawa, MD, Department of Rheumatology, Sasebo City General Hospital, Sasebo, Nagasaki.
Kazusato Hara, MD, Department of Rheumatology, Sasebo City General Hospital, Sasebo, Nagasaki.
Yoshiro Horai, MD, PhD, Department of Rheumatology, Sasebo City General Hospital, Sasebo, Nagasaki.
Atsushi Kawakami, MD, PhD, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan.

Avacopan, a C5a receptor (C5aR) inhibitor, has emerged as a novel treatment for antineutrophil cytoplasmic antibody-associated vasculitis (AAV), providing an alternative to glucocorticoids (GCs).¹ Despite its promising potential, severe liver dysfunction associated with avacopan has been reported in Japan.^2,3.

中文翻译：

在抗中性粒细胞胞质抗体相关血管炎中，缺乏糖皮质激素伴随 avacopan 和随后的肝损伤。

Avacopan 是一种 C5a 受体（C5aR）抑制剂，已成为抗中性粒细胞胞浆抗体相关血管炎（AAV）的新型治疗方法，是糖皮质激素（GC）的替代品。¹ 尽管 avacopan 潜力巨大，但日本已报道与 avacopan 相关的严重肝功能障碍。^2,3.

更新日期：2024-08-15

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