Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and the metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze the production of reactive oxygen species (ROS) without requiring external stimuli and the catalytic substrates are confirmed to be oxygen (O₂) and hydrogen peroxide (H₂O₂) through the computational simulation and experiments. Considering the short of O₂ and H₂O₂ at the tumor site, we utilize calcium peroxide (CaO₂) to supply catalytic substrates for VPQDs and construct nanoparticles together with them, named VPCaNPs. VPCaNPs can induce oxidative stress in tumor cells, particularly characterized by a significant increase in hydroxyl radicals and superoxide radicals, which cause substantial damage to the structure and function of cells, ultimately leading to cell apoptosis. Intriguingly, O₂ provided by CaO₂ can degrade VPQDs slowly, and the degradation product, phosphate, as well as CaO₂-generated calcium ions, can promote tumor calcification. Antitumor immune activation and less metastasis are also observed in VPCaNPs administrated animals. In conclusion, our study unveils the anti-tumor activity of VPQDs as catalysts for generating cytotoxic ROS and the degradation products can promote tumor calcification, providing a promising strategy for treating tumors.

尽管纳米催化医学已在肿瘤治疗中展现出其优势，但其结果严重依赖于底物浓度，且代谢途径仍不明确。我们发现紫磷量子点（VPQDs）可以在不需要外界刺激的情况下催化活性氧（ROS）的产生，并且通过计算确定催化底物是氧气（O ₂ ）和过氧化氢（H ₂ O ₂ ）。模拟和实验。考虑到肿瘤部位缺乏O ₂和H ₂ O ₂ ，​​我们利用过氧化钙(CaO ₂ )为VPQD提供催化底物，并与其一起构建纳米颗粒，命名为VPCaNPs。 VPCaNPs可诱导肿瘤细胞产生氧化应激，特别是羟自由基和超氧自由基显着增加，对细胞的结构和功能造成实质性损害，最终导致细胞凋亡。有趣的是，CaO ₂提供的O ₂可以缓慢降解VPQD，并且降解产物磷酸盐以及CaO ₂生成的钙离子可以促进肿瘤钙化。在给予 VPCaNP 的动物中也观察到抗肿瘤免疫激活和较少的转移。总之，我们的研究揭示了VPQD作为产生细胞毒性ROS的催化剂的抗肿瘤活性，并且降解产物可以促进肿瘤钙化，为治疗肿瘤提供了一种有前景的策略。