Aims:This longitudinal study evaluated the association between childhood family structure and health-related quality of life (HRQoL) at middle age.Methods:The data on childhood family structure at the age of 14 years (‘two-parent family’, ‘one parent not living at home/no information on father’ and ‘father or mother deceased’) and HRQoL (measured by 15D (15-dimensional)) at the age of 46 were collected from the Northern Finland Birth Cohort 1966 using postal questionnaires. We used the binary logistic regression model to estimate the associations between childhood family structures and the lowest 15D quartile (reference: all other quartiles). The associations were adjusted for offspring mothers’ factors during pregnancy (mothers’ educational and occupational status).Results:Of the 6375 participants, the offspring belonging to the ‘one parent not living at home/no information on father’ family structure subgroup had higher odds ratio of belonging to the lowest 15D quartile than the offspring of ‘two-parent families’ (adjusted odds ratio (OR) 1.76, 95% confidence interval (CI) 1.31–2.36, p<0.001 for females; adjusted OR 1.86, 95% CI 1.28–2.70, p=0.001 for males). There were no statistically significant associations between the ‘father or mother deceased’ subgroup and the lowest 15D quartile among the offspring.Conclusions:A single-parent family origin (due to reasons other than parental death) in childhood was significantly associated with impaired HRQoL at middle age. These results provide new perspectives for understanding the long-standing associations on living in a single-parent family.

中文翻译：

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童年家庭结构与中年健康相关生活质量之间的关联：1966 年芬兰北部出生队列的纵向研究


目的：这项纵向研究评估了儿童家庭结构与中年健康相关生活质量（HRQoL）之间的关系。方法：14岁时儿童家庭结构的数据（“双亲家庭”、“一亲家庭”）使用邮寄问卷从 1966 年芬兰北部出生队列中收集了 46 岁时的“父母不住在家里/没有关于父亲”和“父亲或母亲已故”的信息）和 HRQoL（以 15D（15 维）衡量）。我们使用二元逻辑回归模型来估计童年家庭结构与最低 15 维四分位数（参考：所有其他四分位数）之间的关联。这些关联根据后代母亲在怀孕期间的因素（母亲的教育和职业状况）进行了调整。结果：在 6375 名参与者中，属于“单亲不在家/没有父亲信息”家庭结构亚组的后代具有更高的与“双亲家庭”的后代相比，属于最低 15D 四分位数的优势比（调整后优势比 (OR) 1.76，95% 置信区间 (CI) 1.31–2.36，女性 p<0.001；调整后 OR 1.86，95 % CI 1.28–2.70，男性 p=0.001）。 “父亲或母亲已故”亚组与后代中最低 15D 四分位数之间没有统计学上的显着关联。结论：童年时期的单亲家庭（由于父母死亡以外的原因）与 HRQoL 受损显着相关。中年。这些结果为理解单亲家庭生活的长期关联提供了新的视角。