Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration.

中文翻译：

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间充质干细胞治疗骨关节炎：相关细胞治疗的最新进展


骨关节炎（OA）是一种影响整个关节的退行性关节疾病，给全世界的医疗保健系统带来了巨大的负担。尽管传统疗法和靶向软骨细胞疗法在OA治疗和软骨再生方面取得了显着进展，但仍然存在许多问题。来自各种组织的间充质干细胞是研究最多的细胞类型，并已用于 OA 的临床前和临床研究，因为它们更广泛可用，具有更大的治疗能力。体外与自体软骨细胞相比，具有抗炎和免疫调节特性。本文将系统回顾这些领域的最新进展。它可能为改善骨关节炎和软骨再生提供新的见解。