Summary: In this issue, Picco and colleagues provide further evidence that WRN inhibitors are synthetically lethal in microsatellite instability-high (MSI-H) cancers and function by blocking the helicase domain of select WRN residues. They demonstrate that WRN inhibitors may be even more effective in a subset of MSI-high tumors with (TA)n repeat expansions, which represents a possible strategy in clinical development. See related article by Picco et al., p. 1457 (1).

中文翻译：

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WRN 解旋酶：MSI-H 是否比免疫疗法更有效？


摘要：在本期中，Picco 及其同事提供了进一步的证据，证明 WRN 抑制剂在微卫星不稳定性高 (MSI-H) 癌症中具有综合致死性，并通过阻断选定的 WRN 残基的解旋酶结构域发挥作用。他们证明，WRN 抑制剂可能对具有 (TA)n 重复扩增的 MSI 高肿瘤子集更加有效，这代表了临床开发中的一种可能策略。请参阅 Picco 等人的相关文章，第 17 页。 1457（1）。