BACKGROUND The genetic association of allergic rhinitis (AR) with other physiological systems throughout the human body remains unknown. OBJECTIVE The aim of this Mendelian randomization (MR) study was to explore the association of this respiratory disorder with multiple common sleep and neuropsychological disorders at the genetic level. METHODS Summary data for total AR and pollen AR were collected from the most updated FinnGen genome-wide association studies involving more than 340 000 European subjects. Summary data for 12 sleep and neuropsychological disorders (including snoring) were included from UK Biobank studies involving 63 392 to 462 933 European subjects. Three MR methods, including inverse-variance weighting (IVW), weighted median and MR-Egger, were used to determine the relationships between the exposures and outcomes. Several sensitivity analyses, including Cochran's Q, MR-Egger intercept, MR-PRESSO, "leave-one-out" test and funnel plot, were used to detect heterogeneity and horizontal pleiotropy. RESULTS IVW revealed that total and pollen AR were associated with an increased risk of snoring (odds ratio (OR) = 1.011, 95% confidence interval (CI) = 1.004∼1.019, P = .003; OR = 1.006, 95% CI = 1.001∼1.011, P = .014). Two other MR methods supported the results from the IVW analysis. No heterogeneity or horizontal pleiotropy was confirmed by sensitivity analyses. In addition, IVW did not reveal any association between AR and other included disorders. CONCLUSION AR (specifically AR caused by pollen) might be an independent risk factor for snoring at the genetic level, which should be verified in the future.

中文翻译：

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过敏性鼻炎与睡眠和神经心理疾病的遗传关联：孟德尔随机研究。


背景过敏性鼻炎（AR）与整个人体其他生理系统的遗传关联仍然未知。目的 这项孟德尔随机化 (MR) 研究的目的是在基因水平上探讨这种呼吸系统疾病与多种常见睡眠和神经心理疾病的关联。方法 总 AR 和花粉 AR 的摘要数据来自最新的 FinnGen 全基因组关联研究，涉及超过 340 000 名欧洲受试者。英国生物银行研究纳入了 12 种睡眠和神经心理疾病（包括打鼾）的摘要数据，涉及 63 392 至 462 933 名欧洲受试者。三种 MR 方法，包括逆方差加权 (IVW)、加权中位数和 MR-Egger，用于确定暴露与结果之间的关系。几种敏感性分析，包括 Cochran's Q、MR-Egger 截距、MR-PRESSO、“留一”检验和漏斗图，用于检测异质性和水平多效性。结果 IVW 显示总 AR 和花粉 AR 与打鼾风险增加相关（比值比 (OR) = 1.011，95% 置信区间 (CI) = 1.004∼1.019，P = .003；OR = 1.006，95% CI = 1.001∼1.011, P = .014)。另外两种 MR 方法支持 IVW 分析的结果。敏感性分析未证实异质性或水平多效性。此外，IVW 并未揭示 AR 与其他疾病之间的任何关联。结论 AR（特别是花粉引起的AR）可能是基因水平上打鼾的独立危险因素，值得今后进一步验证。