As a stress hormone existing in the human body, cortisol can reflect the psychological stress and health status in daily life, and is a potential biomarker of the body’s stress response. To effectively collect sweat and accurately identify the target, this paper reports a flexible wearable cortisol detection device with outstanding reliability and sensitivity. Molecular imprinted polymer (MIP) ensures cortisol specificity. And carbon nanotubes (CNT) on electrodes increase sensitivity, expanding the detection range to 10⁻³ to 10⁴ nM, with sensitivity at 189.2 nA/lg(nM). In addition, porous chitosan hydrogel (PCSH) collects sweat effectively, its adhesive properties and 80% swelling rate offer a low-cost alternative to microfluidics. Flexible printed circuit board (FPCB) and serpentine electrode (SE) ensure device durability. This non-invasive, highly sensitive device offers a novel method for mental stress monitoring and clinical diagnosis, advancing human physiological state monitoring.

皮质醇作为人体内存在的一种应激激素，可以反映日常生活中的心理压力和健康状况，是人体应激反应的潜在生物标志物。为了有效收集汗液并准确识别目标，本文提出了一种具有出色可靠性和灵敏度的柔性可穿戴皮质醇检测装置。分子印迹聚合物 (MIP) 确保皮质醇的特异性。电极上的碳纳米管（CNT）提高了灵敏度，将检测范围扩大到10 ^-3至10 ⁴ nM，灵敏度为189.2 nA/lg(nM)。此外，多孔壳聚糖水凝胶（PCSH）可以有效地收集汗液，其粘合特性和80%的溶胀率提供了微流体的低成本替代品。柔性印刷电路板（FPCB）和蛇形电极（SE）确保设备的耐用性。这种非侵入性、高灵敏度的设备为精神压力监测和临床诊断提供了一种新方法，推进了人体生理状态监测。