Introduction Given the heterogeneity of sarcoidosis, predicting disease course of patients remains a challenge. Our aim was to determine whether the 3-year change in pulmonary function differed between pulmonary function phenotypes and whether there were differential longitudinal changes by race and sex. Methods We identified individuals seen between 2005 and 2015 with a confirmed diagnosis of sarcoidosis who had at least two pulmonary function test measurements within 3 years of entry into the cohort. For each individual, spirometry, diffusion capacity, Charlson Comorbidity Index, sarcoidosis organ involvement, diagnosis duration, tobacco use, race, sex, age and medications were recorded. We compared changes in pulmonary function by type of pulmonary function phenotype and for demographic groups. Results Of 291 individuals, 59% (173) were female and 54% (156) were black. Individuals with restrictive pulmonary function phenotype had significantly greater 3-year rate of decline of FVC% (forced vital capacity) predicted and FEV1% (forced expiratory volume in 1 s) predicted course when compared with normal phenotype. We identified a subset of individuals in the cohort, highest decliners, who had a median 3-year FVC decline of 156 mL. Black individuals had worse pulmonary function at entry into the cohort measured by FVC% predicted, FEV1% predicted and diffusing capacity for carbon monoxide % predicted compared with white individuals. Black individuals’ pulmonary function remained stable or declined over time, whereas white individuals’ pulmonary function improved over time. There were no sex differences in rate of change in any pulmonary function parameters. Summary We found significant differences in 3-year change in pulmonary function among pulmonary function phenotypes and races, but no difference between sexes. All data relevant to the study are included in the article or uploaded as supplemental information.

中文翻译：

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肺结节病：肺功能随时间变化的差异


简介 鉴于结节病的异质性，预测患者的病程仍然是一个挑战。我们的目的是确定肺功能表型之间的 3 年肺功能变化是否不同，以及种族和性别是否存在差异纵向变化。方法 我们确定了 2005 年至 2015 年间确诊为结节病的个体，他们在进入队列后的 3 年内至少进行了两次肺功能测试测量。记录每个人的肺活量测定、弥散量、查尔森合并症指数、结节病器官受累、诊断持续时间、烟草使用、种族、性别、年龄和药物。我们按肺功能表型类型和人口统计学群体比较了肺功能的变化。结果 在 291 例个体中，59% （173） 为女性，54% （156） 为黑人。与正常表型相比，具有限制性肺功能表型的个体预测的 FVC% （用力肺活量） 预测的 3 年下降率和 FEV1% （1 s 内用力呼气容积） 预测的病程下降率显著更高。我们确定了队列中一部分个体，即下降幅度最大的个体，他们的 3 年 FVC 中位下降了 156 mL。与白人个体相比，黑人个体在进入队列时肺功能较差，通过 FVC% 预测、FEV1% 预测和一氧化碳弥散量 % 预测。黑人的肺功能随着时间的推移保持稳定或下降，而白人的肺功能随着时间的推移而改善。任何肺功能参数的变化率均无性别差异。 摘要 我们发现肺功能表型和种族之间肺功能的 3 年变化存在显著差异，但性别之间没有差异。与研究相关的所有数据都包含在文章中或作为补充信息上传。