Gastric cancer (GC) is one of the most common malignancies and a prominent cause of cancer mortality worldwide. A distinctive characteristic of GC is its intimate association with commensal microbial community. Although Helicobacter pylori is widely recognised as an inciting factor of the onset of gastric carcinogenesis, increasing evidence has indicated the substantial involvement of microbes that reside in the gastric mucosa during disease progression. In particular, dysregulation in gastric microbiota could play pivotal roles throughout the whole carcinogenic processes, from the development of precancerous lesions to gastric malignancy. Here, current understanding of the gastric microbiota in GC development is summarised. Potential translational and clinical implications of using gastric microbes for GC diagnosis, prognosis and therapeutics are also evaluated, with further discussion on conceptual haziness and limitations at present. Finally, we highlight that modulating microbes is a novel and promising frontier for the prevention and management of GC, which necessitates future in-depth investigations.

中文翻译：

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胃癌发展中的胃微生物群和临床意义


胃癌 （GC） 是最常见的恶性肿瘤之一，也是全球癌症死亡的主要原因。GC 的一个显着特征是它与共生微生物群落的密切联系。尽管幽门螺杆菌被广泛认为是胃癌发生发生的诱因，但越来越多的证据表明，在疾病进展过程中，存在于胃粘膜中的微生物大量参与。特别是，胃微生物群的失调可能在从癌前病变发展到胃恶性肿瘤的整个致癌过程中发挥关键作用。这里总结了目前对 GC 发展中胃微生物群的理解。还评估了使用胃微生物进行 GC 诊断、预后和治疗的潜在转化和临床意义，并进一步讨论了目前的概念模糊性和局限性。最后，我们强调调节微生物是预防和管理 GC 的新颖且有前途的前沿领域，这需要未来的深入研究。