BACKGROUND Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as pregnancy and live birth rates, are scarce and based mostly on small case series. OBJECTIVE AND RATIONALE POC was defined as cryopreservation exclusively for prevention of future age-related fertility loss. The primary outcome was live birth rate per patient. The secondary outcomes included the return to thaw rate and laboratory outcomes. A meta-regression analysis examining the association between live birth and age above 40 or below 35 was conducted. SEARCH METHODS We conducted a systematic database search from inception to August 2022. The search included PubMed (MEDLINE) and EMBASE. Our search strategies employed a combination of index terms (Mesh) and free text words to compile relevant concepts. The systematic review and meta-regression were undertaken following registration of systematic review (PROSPERO registration number CRD42022361791) and were reported following guidelines of Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 (PRISMA 2020). OUTCOMES The database search yielded 3847 records. After the selection process, 10 studies, conducted from 1999 to 2020, were included. Overall, 8750 women underwent POC, with a mean cryopreservation age of 37.2 (±0.8). Of those, 1517 women returned to use their oocytes with a return rate of 11.1% (± 4.7%). The mean age at the time of cryopreservation for women who returned to use their oocytes was 38.1 (±0.4), with an average of 12.6 (±3.6) cryopreserved oocytes per woman. In a meta-analysis, the oocyte survival rate was 78.5% with a 95% CI of 0.74–0.83 (I2 = 93%). The live birth rate per patient was 28% with a 95% CI of 0.24–0.33 (I2 = 92%). Overall, 447 live births were reported. In a sub-group analysis, women who underwent cryopreservation at age ≥40 achieved a live birth rate per patient of 19% (95% CI 0.13–0.29, I2 = 6%), while women aged ≤35 years old or younger had a higher live birth rate per patient of 52% (95% CI 0.41–0.63, I2 = 7%). WIDER IMPLICATIONS POC emerges as a feasible option for women aiming to improve their chances of conceiving at a later reproductive age. Nonetheless, it must be acknowledged that the overall success rates of POC are limited and that the likelihood of successful live birth declines as the age at cryopreservation rises. With increasing interest in POC, the collation of comprehensive and high-quality data is imperative to clearly define the outcomes for various age groups. REGISTRATION NUMBER CRD42022361791.

中文翻译：

---

计划卵母细胞冷冻保存：系统评价和荟萃回归分析


背景 对与年龄相关的生育潜力下降的认识增加了计划卵母细胞冷冻保存 （POC） 的普及。然而，关于 POC 结局的数据，包括女性恢复解冻卵母细胞的比率，以及妊娠率和活产率，是稀缺的，并且主要基于小型病例系列。客观和基本原理 POC 被定义为专门用于预防未来与年龄相关的生育能力损失的冷冻保存。主要结局是每位患者的活产率。次要结局包括解冻率和实验室结局。进行了一项 meta 回归分析，检查了活产率与 40 岁以上或 35 岁以下年龄之间的关联。检索方法：我们进行了从建库到 2022 年 8 月的系统数据库检索。检索包括 PubMed （MEDLINE） 和 EMBASE。我们的检索策略采用索引词 （Mesh） 和自由文本词的组合来编译相关概念。系统评价和荟萃回归是在系统评价注册后进行的 （PROSPERO 注册号 CRD42022361791），并按照 2020 年系统评价和荟萃分析的首选报告项目 （PRISMA 2020） 的指南进行报告。结果 数据库检索得到 3847 条记录。选择过程结束后，纳入了 1999 年至 2020 年进行的 10 项研究。总体而言，8750 名女性接受了 POC，平均冷冻保存年龄为 37.2 （±0.8）。其中，1517 名女性返回使用她们的卵母细胞，回收率为 11.1% （± 4.7%）。返回使用卵母细胞的女性冷冻保存时的平均年龄为 38.1 （±0.4），平均每位女性 12.6 （±3.6） 个冷冻保存的卵母细胞。在一项荟萃分析中，卵母细胞存活率为 78.5%，95% CI 为 0.74-0。83 （I2 = 93%）。每位患者的活产率为 28%，95% CI 为 0.24-0.33 （I2 = 92%）。总共报告了 447 例活产婴儿。在亚组分析中，在 ≥40 岁时接受冷冻保存的女性每位患者的活产率为 19% （95% CI 0.13-0.29，I2 = 6%），而 ≤35 岁或以下女性的每位患者活产率更高，为 52% （95% CI 0.41-0.63，I2 = 7%）。更广泛的影响 POC 成为旨在提高她们在晚育年龄受孕机会的女性的可行选择。尽管如此，必须承认 POC 的总体成功率是有限的，并且成功活产的可能性随着冷冻保存年龄的增加而下降。随着人们对 POC 的兴趣日益浓厚，必须整理全面和高质量的数据，以明确定义不同年龄组的结果。注册号 CRD42022361791。