BackgroundNo widely accepted, validated instrument currently exists to measure clinical outcomes in patients who undergo dacryocystorhinostomy (DCR) for treatment of epiphora.ObjectiveTo develop a patient-reported outcome measure applicable to this population.MethodsPsychometric evaluations, consultation with experts, and review of the literature informed item generation of a 12-question questionnaire to incorporate the most relevant symptoms experienced by patients with nasolacrimal duct obstruction. This questionnaire, known as the Tearing Assessment and Rating Scale-12 (TEARS-12), was administered to 32 patients before and after intervention, in the form of endoscopic DCR. Statistical analysis was performed to measure internal consistency, responsiveness, and test-retest reliability.ResultsPre-operative and post-operative TEARS-12 scores (28.2 [standard error (SE) 3.19] vs 11.8 [SE 3.25], respectively, P = 0.001) demonstrated improved patient outcome within 6 weeks following endoscopic DCR. Cronbach's alpha for the questionnaire was 0.90, indicating high overall reliability. Additionally, each question demonstrated internal reliability, with a corrected item-total correlation greater than 0.30. The intraclass correlation between the two pre-operative scores was 0.858 ( P < 0.001), indicating high test-retest reliability.ConclusionTEARS-12 is a statistically valid, easy-to-administer instrument to measure clinical outcomes in patients who undergo endoscopic DCR.

中文翻译：

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手术治疗溢泪的新患者报告结果测量：撕裂评估和评定量表-12 (TEARS-12)


背景目前尚无广泛接受的、经过验证的仪器来测量接受泪囊鼻腔吻合术 (DCR) 治疗溢泪的患者的临床结果。目的开发适用于该人群的患者报告的结果测量方法。方法心理测量评估、专家咨询和文献回顾生成包含 12 个问题的调查问卷，纳入鼻泪管阻塞患者经历的最相关症状。该问卷被称为撕裂评估和评定量表-12 (TEARS-12)，以内窥镜 DCR 的形式在干预前后对 32 名患者进行了调查。进行统计分析以衡量内部一致性、反应性和重测可靠性。结果术前和术后 TEARS-12 评分分别为 28.2 [标准误差 (SE) 3.19] vs 11.8 [SE 3.25]，P = 0.001 ）证明内镜 DCR 后 6 周内患者预后得到改善。问卷的 Cronbach's alpha 值为 0.90，总体信度较高。此外，每个问题都显示了内部可靠性，校正后的项目总相关性大于 0.30。两次术前评分之间的组内相关性为 0.858（P < 0.001），表明重测可靠性较高。结论 TEARS-12 是一种统计上有效、易于管理的工具，用于测量接受内镜 DCR 患者的临床结果。