BackgroundEndoscopic sinus surgery (ESS) could significantly improve olfactory function among patients with chronic rhinosinusitis (CRS). This study aimed to perform a meta-analysis to evaluate the effect of ESS on the olfactory bulb volume (OBV) among patients with CRS.MethodsA systemic search of PubMed, Medline, Embase, Web of Science, and other databases was conducted to identify studies assessing OBV changes in patients with CRS after ESS utilizing magnetic resonance imaging.ResultsA total of four studies with 168 participants were included. Comparing the changes in OBV of patients with CRS before and after surgery within 3-6 months, the ESS significantly improved the overall OBV ( P = 0.005, I2 = 66%), with the left OBV increased by 5.57mm3 ( P = 0.84, I2 = 0%), and the right OBV increased by 8.63mm3 ( P = 0.09, I2 = 53%). A difference in OBV persists between healthy controls and patients with CRS 3-6 months after ESS. The overall OBV of patients with CRS after ESS was significantly smaller than controls (mean difference = -3.84, P = 0.04), with a mean difference of 4.13mm3 on the left side ( P = 0.72, I2 = 0%), and a mean difference of 3.22mm3 on the right side ( P = 0.0001, I2 = 89%).ConclusionsESS significantly increases the OBV among patients with CRS.

中文翻译：

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内窥镜鼻窦手术对慢性鼻窦炎患者嗅球体积的影响：系统评价和荟萃分析


背景内窥镜鼻窦手术（ESS）可以显着改善慢性鼻窦炎（CRS）患者的嗅觉功能。本研究旨在进行荟萃分析，以评估 ESS 对 CRS 患者嗅球体积 (OBV) 的影响。方法对 PubMed、Medline、Embase、Web of Science 和其他数据库进行系统检索以识别研究利用磁共振成像评估 ESS 后 CRS 患者的 OBV 变化。结果 总共纳入了四项研究，共有 168 名参与者。比较CRS患者手术前后3-6个月内OBV的变化，ESS显着改善了整体OBV（ P = 0.005，I 2 = 66%），左侧OBV增加5.57mm 3 （ P = 0.84，我2 = 0%），右侧OBV增加8.63mm 3 （ P = 0.09，我2 = 53%）。 ESS 后 3-6 个月，健康对照者和 CRS 患者之间的 OBV 仍然存在差异。 ESS后CRS患者的总体OBV显着小于对照组（平均差=-3.84，P=0.04），平均差为4.13mm 3在左侧（ P = 0.72，我2 = 0%)，平均差为 3.22mm 3在右侧（ P = 0.0001，我2 = 89%）。结论 ESS 显着增加了 CRS 患者的 OBV。