<br>传统食用植物麦冬中皂苷的镇静和催眠作用。 PCPA 诱导的失眠小鼠,Journal of Ethnopharmacology

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传统食用植物麦冬中皂苷的镇静和催眠作用。 PCPA 诱导的失眠小鼠
Journal of Ethnopharmacology ( IF 4.8 ) Pub Date : 2024-03-12 , DOI: 10.1016/j.jep.2024.118049
Yi-Meng Li ₁ , Chun-Yan Shen ₂ , Jian-Guo Jiang ₁

Affiliation

Lour.是列入《药食同源植物名录》的物种，传统上用于治疗疲劳、烦躁、失眠和便秘。本研究旨在评估天然植物 Lour 中皂苷的镇静和催眠作用。。从中提取总皂苷（LSTS）和纯化皂苷（LSPS），然后使用HPLC-MS对其主要成分进行彻底分析。随后，通过 PCPA 诱导的小鼠焦虑和抑郁行为的改善来评估 LSTS 和 LSPS 的治疗效果。 LSTS和LSPS的皂苷组成相似，但组成比例不同，LSTS中麦冬苷类皂苷所占比例较大。研究表明，LSTS 和 LSPS 都可以延长 PCPA 诱导小鼠的睡眠持续时间和不动时间，同时缩短睡眠潜伏期。然而，各组小鼠的体重变化没有显着差异。 Elisa结果表明，LSTS和LSPS可以降低小鼠血浆中NE、DA、IL-6的水平，升高5-HT、NO、PGD2和TNF-α的水平。 LSTS增强神经递质受体的表达，而LSPS在调节炎症因子表达方面表现出更明显的作用。总之，从中提取的皂苷可能有望作为开发具有镇静和催眠作用的保健食品的成分，可能与血清素能和 GABA 能神经元表达的调节以及免疫调节过程有关。

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Sedative and hypnotic effects of the saponins from a traditional edible plant Liriope spicata Lour. in PCPA-induced insomnia mice

Lour., a species listed in the catalogue of ‘Medicinal and Edible Homologous Species’, is traditionally used for the treatment of fatigue, restlessness, insomnia and constipation. This study is aimed to evaluate the sedative and hypnotic effect of the saponins from a natural plant Lour. . The total saponin (LSTS) and purified saponin (LSPS) were extracted from , followed by a thorough analysis of their major components using the HPLC-MS. Subsequently, the therapeutic efficacy of LSTS and LSPS was evaluated by the improvement of anxiety and depression behaviors of the PCPA-induced mice. LSTS and LSPS exhibited similar saponin compositions but differ in their composition ratios, with liriopesides-type saponins accounting for a larger proportion in LSTS. Studies demonstrated that both LSTS and LSPS can extend sleep duration and immobility time, while reducing sleep latency in PCPA-induced mice. However, there was no significant difference in weight change among the various mice groups. Elisa results indicated that the LSTS and LSPS could decrease levels of NE, DA, IL-6, and elevate the levels of 5-HT, NO, PGD2 and TNF-α in mice plasma. LSTS enhanced the expression of neurotransmitter receptors, while LSPS exhibited a more pronounced effect in regulating the expression of inflammatory factors. In conclusion, the saponins derived from might hold promise as ingredients for developing health foods with sedative and hypnotic effects, potentially related to the modulation of serotonergic and GABAergic neuron expression, as well as immunomodulatory process.

更新日期：2024-03-12

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