BackgroundDespite advances in surgical techniques, recurrence rates after endoscopic sinus surgery (ESS) for chronic rhinosinusitis with nasal polyps (CRSwNP) remain high and difficult to predict.ObjectiveThis study aimed to evaluate the potential role of microRNA 125b (miR-125b) in predicting disease evolution following ESS.MethodsWe conducted a prospective study including patients undergoing first ESS for CRSwNP in our department between January 2020 and November 2021. We determined miR-125b levels from nasal polyps and pursued a standardized follow-up for at least 18 months for each patient.ResultsA total of 86 patients were included in the study. Higher postoperative endoscopy scores were associated with more severe disease at presentation on computed tomography scan, presence of concomitant asthma, and higher values of miR-125b. Even after multivariate repeated measures analysis and adjustments for confounders, miR-125b remained statistically significant. Moreover, miR-125 was the most important factor in predicting disease evolution at 18 months.ConclusionA clear, robust relation between nasal polyp control evaluated through objective measures and miR-125b values was observed. This finding indicates the potential role of miR-125b in predicting the course of the disease following ESS.

中文翻译：

---

MicroRNA-125b 是慢性鼻窦炎伴鼻息肉手术结果的潜在预测因子


背景尽管手术技术取得了进步，但内窥镜鼻窦手术（ESS）治疗慢性鼻窦炎伴鼻息肉（CRSwNP）后的复发率仍然很高且难以预测。目的本研究旨在评估微小RNA 125b（miR-125b）在预测疾病中的潜在作用方法我们进行了一项前瞻性研究，包括 2020 年 1 月至 2021 年 11 月期间在我们科室接受首次 ESS 治疗 CRSwNP 的患者。我们测定了鼻息肉中的 miR-125b 水平，并对每位患者进行了至少 18 个月的标准化随访结果共有86名患者纳入研究。术后内窥镜评分越高，计算机断层扫描显示的疾病越严重、伴有哮喘以及 miR-125b 值越高。即使在多变量重复测量分析和混杂因素调整后，miR-125b 仍然具有统计学显着性。此外，miR-125 是预测 18 个月时疾病进展的最重要因素。结论 通过客观测量评估的鼻息肉控制与 miR-125b 值之间观察到明显、稳健的关系。这一发现表明 miR-125b 在预测 ESS 后疾病进程中的潜在作用。