<br>用于固体癌症成像和治疗的肽功能化无机氧化物纳米材料,Advanced Materials

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用于固体癌症成像和治疗的肽功能化无机氧化物纳米材料
Advanced Materials ( IF 27.4 ) Pub Date : 2024-02-09 , DOI: 10.1002/adma.202311548
Xiaolin Duan _{1,

2,

3} , Pin Wang _{1,

2,

3} , Lulu He _{1,

2} , Zhen He _{1,

2,

3} , Shiwei Wang _{1,

2,

3} , Fang Yang _{1,

2} , Changyong Gao _{1,

2} , Wenzhi Ren _{1,

2} , Jie Lin _{1,

2} , Tianxiang Chen _{1,

2} , Chen Xu _{1,

2} , Juan Li _{1,

2} , Aiguo Wu _{1,

2}

Affiliation

实体瘤的诊断和治疗已经取得了显着的进步，其特点是特异性增强以及成像和治疗功能的整合。无机氧化物纳米材料（ION）具有光学、磁力、超声波和生化调节特性的多面性，使其成为开发多功能纳米平台的理想构建模块。在这种背景下出现的一类有前途的材料是肽功能化无机氧化物纳米材料（PFION），它在多功能成像和治疗方面表现出优异的性能，使其成为推进实体瘤诊断和治疗的潜在候选材料。由于肽在肿瘤靶向、渗透、反应和治疗方面的功能，精心设计的PFION可以在实体瘤部位特异性积累和释放治疗剂或显像剂，从而实现精确成像和有效治疗。本综述概述了使用 PFION 进行实体瘤成像和治疗的最新进展，强调了成像和治疗整合以及协同治疗的优越性。此外，该综述还深入讨论了PFIONs的挑战和前景，旨在通过优化材料系统促进跨学科交叉，促进其临床转化和个性化诊断和治疗系统的发展。

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Peptide-Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy

The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity and integration of imaging and therapeutic functions. The multifaceted nature of inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, and biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class of materials that have emerged in this context are peptide-functionalized inorganic oxide nanomaterials (PFIONs), which have demonstrated excellent performance in multifunctional imaging and therapy, making them potential candidates for advancing solid tumor diagnosis and treatment. Owing to the functionalities of peptides in tumor targeting, penetration, responsiveness, and therapy, well-designed PFIONs can specifically accumulate and release therapeutic or imaging agents at the solid tumor sites, enabling precise imaging and effective treatment. This review provides an overview of the recent advances in the use of PFIONs for the imaging and treatment of solid tumors, highlighting the superiority of imaging and therapeutic integration as well as synergistic treatment. Moreover, the review discusses the challenges and prospects of PFIONs in depth, aiming to promote the intersection of the interdisciplinary to facilitate their clinical translation and the development of personalized diagnostic and therapeutic systems by optimizing the material systems.

更新日期：2024-02-09

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