Metastructure “Trap” Coating by Acoustic Confinement Effect for Antibacterial Sonothermal Therapy,Advanced Functional Materials

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Metastructure “Trap” Coating by Acoustic Confinement Effect for Antibacterial Sonothermal Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-01-30 , DOI: 10.1002/adfm.202316093
Shiwei Guan _{1,

2} , Shuhan Chen _{1,

2} , Xianming Zhang ₁ , Haifeng Zhang ₃ , Xingdan Liu _{1,

2} , Zhiyu Hou _{1,

2} , Fang Wang _{1,

2} , Shi Qian _{1,

2} , Hongqin Zhu ₁ , Ji Tan ₁ , Xuanyong Liu _{1,

2,

3}

Affiliation

Antibacterial sonothermal therapy (ASTT) is attractive for treating implant-associated infection, which addresses the limitations of poor penetration of photothermal therapy. However, achieving implant surface-specific ultrasound heating is incredibly challenging. Inspired by the porous acoustic metastructure in noise reduction, the acoustic metastructure would be a new strategy for attaining ASTT. Herein, an “acoustic confinement effect” is proposed to “trap” ultrasound for the metastructure TiO₂ porous coating on titanium implants. The metastructure coating accomplishes specific acoustic absorption and efficient acoustic-to-thermal conversion, surpassing the non-specific heating of conventional coatings. The theoretical calculation and experiment of metastructure porous coating prove the acoustic-to-thermal conversion mechanism, which is also validated in metastructure porous coatings on medical polyetheretherketone, indicating it is universal. Excitingly, this acoustic metastructure “trap” can capture bacteria and local sonothermal enhancement, exhibiting superior ASTT antibacterial rates (S. aureus, 99.69%; E. coil, 99.58%) at low-power ultrasound. In addition, the metastructure TiO₂ coating mimics human bone and demonstrates outstanding osseointegration. This study sheds substantial light on developing the acoustic responsive surface, broadening a new direction of acoustic metamaterials in medical applications.

中文翻译：

用于抗菌声热治疗的声约束效应超结构“陷阱”涂层

抗菌声热疗法（ASTT）对于治疗植入相关感染很有吸引力，它解决了光热疗法渗透性差的局限性。然而，实现植入物表面特定的超声波加热非常具有挑战性。受降噪中多孔声学元结构的启发，声学元结构将成为实现 ASTT 的新策略。在此，提出了“声限制效应”来“捕获”超声用于钛植入物上的超结构 TiO ₂ 多孔涂层。超结构涂层实现了特定的吸声和高效的声热转换，超越了传统涂层的非特定加热。超结构多孔涂层的理论计算和实验证明了声热转换机理，该机理在医用聚醚醚酮超结构多孔涂层中也得到了验证，表明其具有普适性。令人兴奋的是，这种声学元结构“陷阱”可以捕获细菌并进行局部声热增强，在低功率超声下表现出优异的 ASTT 抗菌率（金黄色葡萄球菌，99.69%；大肠杆菌，99.58%）。此外，超结构TiO ₂ 涂层模仿人骨并表现出出色的骨整合能力。这项研究为开发声响应表面提供了重要线索，拓宽了声学超材料在医学应用中的新方向。

更新日期：2024-01-30

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