Structure-Activity Relationship Study to Develop Peptide Amphiphiles as Species-Specific Antimicrobials,Chemistry - A European Journal

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Structure-Activity Relationship Study to Develop Peptide Amphiphiles as Species-Specific Antimicrobials
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2024-01-14 , DOI: 10.1002/chem.202303986
Aramis J Pereira ₁ , Huihua Xing _{1,

2} , Luana J de Campos ₁ , Mohamed A Seleem ₃ , Kelly M P de Oliveira ₄ , Stephen K Obaro _{5,

6} , Martin Conda-Sheridan ₁

Affiliation

Antimicrobial peptide amphiphiles nanostructures were studied regarding the supramolecular structure-activity and the key structure contributors for activity. For Staphylococcus aureus the zeta potential was more important while Gram-negative bacteria were more influenced by LogP. Mechanism of action and an in vivo study was also performed. We showed these nanostructures can be an intriguing platform for the development of novel nanoantibacterials.

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