Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane-Anchoring Ability and Cellular Internalization,Angewandte Chemie International Edition

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Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane-Anchoring Ability and Cellular Internalization
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-01-09 , DOI: 10.1002/anie.202312755
He Xia ₁ , Wenjuan Zhou ₂ , Dezheng Li ₁ , Fan Peng ₂ , Liyang Yu ₁ , Yuanhua Sang ₁ , Hong Liu ₁ , Aijun Hao ₂ , Jichuan Qiu ₁

Affiliation

A tunable hydrophobic protrusion was created on Janus particles to regulate the nanoparticle-cell membrane interactions. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, lead the particle to dock to the membrane, and then draw the whole particle into the cell, improving the efficiencies of both membrane-anchoring and cellular internalization.

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