Fenofibrate is widely used as a lipid-lowering drug. However, fenofibrate has a short half-life, so it needs to be prepared as a sustained-release preparation to prolong the administration time. In this study, fenofibrate nanofibers are prepared by electrospinning using the biodegradable material polylactic acid as a drug carrier. To improve the hydrophilicity and cumulative drug release rate, polyvinylpyrrolidone is introduced to prepare a composite drug-loaded nanofibrous membrane. The experimental results show that the hydrophilicity and cumulative release rate are improved. This study provides a simple and efficient method for the preparation of fenofibrate nanofibrous membranes with sustained-release effects.

非诺贝特作为降脂药被广泛使用。但非诺贝特半衰期短，需要制备成缓释制剂以延长给药时间。本研究以生物可降解材料聚乳酸为药物载体，通过静电纺丝法制备非诺贝特纳米纤维。为了提高亲水性和累积药物释放率，引入聚乙烯吡咯烷酮制备复合载药纳米纤维膜。实验结果表明，亲水性和累积释放率均得到提高。该研究为制备具有缓释作用的非诺贝特纳米纤维膜提供了一种简单高效的方法。