<br>设计和合成水基纳米递送农药系统以提高功效和安全性,ACS Nano

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设计和合成水基纳米递送农药系统以提高功效和安全性
ACS Nano ( IF 15.8 ) Pub Date : 2023-12-22 , DOI: 10.1021/acsnano.3c08854
Changcheng An _{1,

2} , Bingna Huang ₁ , Jiajun Jiang ₁ , Xinyue Wang ₁ , Ningjun Li ₁ , Huihui Liu ₁ , Yue Shen ₁ , Changjiao Sun ₁ , Shenshan Zhan ₁ , Xingye Li ₁ , Chong Wang ₁ , Zhanghua Zeng ₁ , Haixin Cui ₁ , Qingjun Wu ₃ , Youjun Zhang ₃ , Zhiling Guo ₄ , Peng Zhang ₄ , Iseult Lynch ₄ , Jin-Ming Gao ₂ , Yan Wang ₁

Affiliation

开发环境友好且安全的纳米递送系统对于提高农药的功效并最大程度地减少环境和健康风险至关重要。然而，在不使用有害溶剂的情况下制备完全水基的纳米农药是一个技术挑战。在本研究中，构建了水基纳米递送农药系统，以提高埃玛菌素苯甲酸酯（EB）的功效和安全性。设计了一种特定的表面活性剂 29-(4-(5-羟基壬-5-基)苯氧基)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB)与 EB 合成形成水基纳米递送系统 (EBWNS)。分子动力学模拟揭示了 SurEB 和 EB 在水中的自组装和相互作用力，为了解 EBWNS 纳米颗粒的形成机制提供了见解。纳米递送系统显示出 EB 的持久有效性和减少的降解，并对多种目标害虫表现出良好的防治效果，例如红蜘蛛、甜菜夜蛾幼虫（鳞翅目：夜蛾科）和水稻二化螟（二化螟）。对各种物体的毒理学测试表明，EBWNS对种子、HaCaT细胞、斑马鱼、蚯蚓和大肠杆菌具有低毒性。这项研究为开发环境友好型纳米农药制剂提供了独特的视角，阐明了特定脂溶性农药的水基处理方法。水基纳米递送农药系统具有提高农药在田间施用过程中的功效和安全性的潜力。

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Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety

Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5-yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications.

更新日期：2023-12-22

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