Endowing Polyetheretherketone with Anti-Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection,Advanced Healthcare Materials

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Endowing Polyetheretherketone with Anti-Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-12-02 , DOI: 10.1002/adhm.202302873
Xinxin Bai ₁ , Xintian Zhang ₂ , Jiecheng Xiao ₁ , Xingyu Lin ₁ , Rongjie Lin ₁ , Rui Zhang ₁ , Xiaoqin Deng ₂ , Menghan Zhang ₂ , Wenqin Wei ₃ , Bin Lan ₃ , Shaohuang Weng ₂ , Min Chen ₁

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Methicillin-resistant Staphylococcus aureus (MRSA) infection and compromised immunity are the severe complications associated with implantation surgery in diabetes mellitus. Enhancing the antibacterial and immunomodulatory properties of implants represents an effective approach to improve the osseointegration of implant in diabetes mellitus. Herein, guanidination carbon dots (GCDs) with antibacterial and immunoregulatory functions are synthesized. The GCDs demonstrate killing effect on MRSA without detectable induced resistance. Additionally, they promote the polarization of macrophages from the M1 to M2 subtype, with the inhibiting pro-inflammatory cytokines and promoting anti-inflammatory factors. Correspondingly, GCDs are immobilized onto sulfonated polyether ether ketone (SP@GCDs) using a polyvinyl butyraldehyde (PVB) coating layer through soaking-drying technique. SP@GCDs maintain stable antibacterial efficacy against MRSA for six consecutive days and retain the immunomodulatory function, while also possessing the long-term storage stability and biocompatibility of more than 6 months. Moreover, SP@GCDs significantly promote the proliferation and mineralization of osteoblasts. SP@GCDs facilitate osteogenesis through immunoregulatory. Additionally, SP@GCDs exert stable antibacterial and immune regulatory functions in implantation site of a diabetes rat, effectively promoting implant osseointegration regardless of the MRSA infection. These findings provide valuable insights into implant modification through designing nanomaterials with multifunction for enhancing osseointegration of diabetes mellitus, suggesting the promising clinical application prospects.

中文翻译：

通过胍基碳点修饰赋予聚醚醚酮抗感染和免疫调节特性，促进 MRSA 感染糖尿病患者的骨整合

耐甲氧西林金黄色葡萄球菌(MRSA) 感染和免疫力受损是糖尿病植入手术相关的严重并发症。增强植入物的抗菌和免疫调节特性是改善糖尿病植入物骨整合的有效方法。在此，合成了具有抗菌和免疫调节功能的胍基碳点（GCD）。 GCD 表现出对 MRSA 的杀伤作用，且未检测到诱导耐药性。此外，它们还促进巨噬细胞从 M1 亚型极化为 M2 亚型，同时抑制促炎细胞因子并促进抗炎因子。相应地，使用聚乙烯醇丁醛（PVB）涂层通过浸泡干燥技术将GCD固定在磺化聚醚醚酮（SP@GCDs）上。 SP@GCDs可连续六天保持稳定的针对MRSA的抗菌功效并保留免疫调节功能，同时还具备6个月以上的长期储存稳定性和生物相容性。此外，SP@GCDs 显着促进成骨细胞的增殖和矿化。 SP@GCDs 通过免疫调节促进成骨。此外，SP@GCDs在糖尿病大鼠的植入部位发挥稳定的抗菌和免疫调节功能，无论MRSA感染如何，都能有效促进种植体骨整合。这些发现为通过设计多功能纳米材料来增强糖尿病骨整合的种植体修饰提供了有价值的见解，表明了良好的临床应用前景。

更新日期：2023-12-02

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