外膜蛋白和外排泵介导沙门氏菌的多药耐药性：对抗菌治疗的威胁日益增加,ACS Infectious Diseases

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外膜蛋白和外排泵介导沙门氏菌的多药耐药性：对抗菌治疗的威胁日益增加
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2023-11-01 , DOI: 10.1021/acsinfecdis.3c00408
Sadanand Dangari Akshay ₁ , Vijaya Kumar Deekshit ₂ , Juliet Mohan Raj ₂ , Biswajit Maiti ₁

Affiliation

尽管近几十年来抗生素治疗取得了巨大成就，但耐药病原体仍然是全球死亡和经济损失的主要原因。世界卫生组织关键病原体之一是沙门氏菌。对沙门氏菌感染的广泛和不适当的治疗导致了从多重耐药性（MDR）到广泛耐药性（XDR）。外排介导系统和外膜蛋白 (OMP) 之间的协同作用可能有利于沙门氏菌的 MDR 。外排系统和 OMP（内流）的差异表达以及位置突变是与耐药性发展相关的因素。深入了解抗生素流入和流出的机制有助于开发结构稳定的分子，该分子能够熟练地逃离沙门氏菌的耐药循环。当前需要了解国家、区域和全球各级应对耐药性激增的战略责任并制定政策。在这篇综述中，我们试图汇总所有可用的研究结果，并通过剖析 OMP 和外排系统的参与来描述耐药机制。将主要 OMP 与沙门氏菌中的外排系统的差异表达和位置突变相结合，可以为开发针对一种健康应用的战略疗法提供见解。

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Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant pathogens have remained a leading cause of death and economic loss globally. One such WHO-critical group pathogen is Salmonella. The extensive and inappropriate treatments for Salmonella infections have led from multi-drug resistance (MDR) to extensive drug resistance (XDR). The synergy between efflux-mediated systems and outer membrane proteins (OMPs) may favor MDR in Salmonella. Differential expression of the efflux system and OMPs (influx) and positional mutations are the factors that can be correlated to the development of drug resistance. Insights into the mechanism of influx and efflux of antibiotics can aid in developing a structurally stable molecule that can be proficient at escaping from the resistance loops in Salmonella. Understanding the strategic responsibilities and developing policies to address the surge of drug resistance at the national, regional, and global levels are the needs of the hour. In this Review, we attempt to aggregate all the available research findings and delineate the resistance mechanisms by dissecting the involvement of OMPs and efflux systems. Integrating major OMPs and the efflux system’s differential expression and positional mutation in Salmonella may provide insight into developing strategic therapies for one health application.

更新日期：2023-11-01

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