<br>无创时间干扰电刺激人体海马,Nature Neuroscience

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无创时间干扰电刺激人体海马
Nature Neuroscience ( IF 21.2 ) Pub Date : 2023-10-19 , DOI: 10.1038/s41593-023-01456-8
Ines R Violante ₁ , Ketevan Alania _{2,

3} , Antonino M Cassarà ₄ , Esra Neufeld ₄ , Emma Acerbo _{5,

6} , Romain Carron _{5,

7} , Adam Williamson _{5,

8} , Danielle L Kurtin ₁ , Edward Rhodes _{2,

3} , Adam Hampshire ₂ , Niels Kuster _{4,

9} , Edward S Boyden _{10,

11} , Alvaro Pascual-Leone _{12,

13} , Nir Grossman _{2,

3}

Affiliation

School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Department of Brain Sciences, Imperial College London, London, UK.
UK Dementia Research Institute, Imperial College London, London, UK.
Foundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland.
Institut de Neurosciences des Systèmes, Aix-Marseille University, INSERM, Marseille, France.
Department of Neurology and Neurosurgery, Emory University Hospital, Atlanta, GA, USA.
Department of Functional and Stereotactic Neurosurgery, Timone University Hospital, Marseille, France.
International Clinical Research Center, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland.
Departments of Brain and Cognitive Sciences, Media Arts and Sciences, and Biological Engineering, McGovern and Koch Institutes, Massachusetts Institute of Technology, Cambridge, MA, USA.
Howard Hughes Medical Institute, Cambridge, MA, USA.
Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.

通过植入电极进行的深部脑刺激（DBS）在全世界范围内用于治疗患有严重神经和精神疾病的患者。然而，其侵入性阻碍了广泛的临床使用和研究部署。时间干扰（TI）是一种非侵入性可操纵 DBS 策略，使用多个 kHz 范围的电场，其频率在神经活动范围内。在这里，我们报告了非侵入性 DBS 概念在人体中的验证。我们在人体尸体上使用电场建模和测量来验证经颅 TI 刺激的位置可以可控地集中在海马体中，同时最大限度地减少对上层皮层的暴露。然后，我们使用功能磁共振成像和行为实验来证明 TI 刺激可以集中调节海马活动并提高健康人情景记忆的准确性。我们的结果证明了对人脑深层结构的有针对性的、非侵入性的电刺激。

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更新日期：2023-10-20

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