An Axially Chiral Styrene–Phosphine Ligand for Pd-Catalyzed Asymmetric N-Alkylation of Indoles,The Journal of Organic Chemistry

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An Axially Chiral Styrene–Phosphine Ligand for Pd-Catalyzed Asymmetric N-Alkylation of Indoles
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-10-04 , DOI: 10.1021/acs.joc.3c01734
Zhen-Bang Chen ₁ , Ru-Xin Liu ₁ , Zi-Hao Li ₁ , Tong-Mei Ding ₁ , He-Yuan Bai ₁ , Zengming Shen ₁ , Shu-Yu Zhang _{1,

2}

Affiliation

An efficient palladium-catalyzed enantioselective direct N-alkylation of indoles using a novel type of axially chiral styrene-phosphine ligand SJTU-PHOS-1 was developed. This reaction demonstrated good functional group compatibility and a wide range scope of substrates in mild conditions. Moreover, the DFT calculations expounded the coordination mode of the metal catalyst and the axially chiral styrene-phosphine ligand in the enantioselectivity control.

中文翻译：

钯催化吲哚不对称 N-烷基化的轴向手性苯乙烯-膦配体

使用新型轴向手性苯乙烯-膦配体SJTU-PHOS-1开发了一种高效的钯催化吲哚对映选择性直接N-烷基化反应。该反应在温和条件下表现出良好的官能团相容性和广泛的底物范围。此外，DFT计算阐述了金属催化剂与轴向手性苯乙烯-膦配体在对映选择性控制中的配位模式。

更新日期：2023-10-04

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