<br>脂质代谢在骨质疏松症中的作用：临床意义和细胞机制,Genes & Diseases

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脂质代谢在骨质疏松症中的作用：临床意义和细胞机制
Genes & Diseases ( IF 6.9 ) Pub Date : 2023-09-20 , DOI: 10.1016/j.gendis.2023.101122
Jing Zhang _{1,

2} , Wenhui Hu ₂ , Zhi Zou ₁ , Yuheng Li ₂ , Fei Kang ₂ , Jianmei Li ₂ , Shiwu Dong _{2,

3}

Affiliation

近年来，研究人员开始关注脂质与骨代谢平衡之间的关系。此外，许多与脂质代谢紊乱相关的疾病，如非酒精性脂肪肝、动脉粥样硬化、肥胖和更年期，都与骨质疏松表型相关。临床观察到，这些脂质代谢紊乱会促进骨质疏松相关指标骨密度和骨量的变化。此外，在高脂肪和高胆固醇诱导的动物模型中观察到类似的骨质疏松表型变化。脂质代谢异常（例如氧化脂质增加和血浆胆固醇升高）通过跨器官通讯影响骨微环境稳态，促进间充质干细胞向脂肪细胞分化，并抑制向成骨细胞的分化。此外，脂质代谢紊乱可促进成骨细胞分泌核因子κB配体受体激活剂等细胞因子，刺激破骨细胞分化，从而影响骨代谢平衡。最后，本综述探讨了脂质代谢紊乱与骨质疏松症之间可能存在的联系，并阐明了脂质代谢影响骨代谢平衡的潜在调节机制和信号通路。我们还总结了干预脂质代谢治疗骨质疏松症的可能途径和前景。

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The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

In recent years, researchers have become focused on the relationship between lipids and bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders, such as nonalcoholic fatty liver disease, atherosclerosis, obesity, and menopause, are associated with osteoporotic phenotypes. It has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone mass. Furthermore, similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal models. Abnormal lipid metabolism (such as increased oxidized lipids and elevated plasma cholesterol) affects bone microenvironment homeostasis via cross-organ communication, promoting differentiation of mesenchymal stem cells to adipocytes, and inhibiting commitment towards osteoblasts. Moreover, disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cytokines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of osteoclasts. Conclusively, this review addresses the possible link between lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism balance. We also summarize the possible approaches and prospects of intervening lipid metabolism for osteoporosis treatment.

更新日期：2023-09-20

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