Two complex hasubanan alkaloids were synthesized from inexpensive cyclohexanedione monoethylene acetal by a divergent route featuring a palladium-catalyzed cascade cyclization. Regioselective Baeyer–Villiger oxidation followed by MeNH₂-triggered skeletal reorganization formed the benzannulated aza[4.4.3]propellane, and late-stage regio- and diastereoselective oxidative annulation of a sp³ C−H bond formed the challenging tetrahydrofuran ring system.

中文翻译：

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Metaphanine 和 Oxoepistephamiersine 的全合成

通过钯催化级联环化的不同路线，由廉价的环己二酮单乙烯缩醛合成了两种复杂的哈苏巴南生物碱。区域选择性Baeyer-Villiger氧化随后MeNH ₂触发的骨架重组形成了苯并环氮杂[4.4.3]丙烷，而sp ³ C−H键的后期区域和非对映选择性氧化环形成了具有挑战性的四氢呋喃环系统。