Cancer cell membrane-coated bacterial ghosts for highly efficient paclitaxel delivery against metastatic lung cancer,Acta Pharmaceutica Sinica B

当前位置： X-MOL 学术 › Acta Pharm. Sin. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cancer cell membrane-coated bacterial ghosts for highly efficient paclitaxel delivery against metastatic lung cancer
Acta Pharmaceutica Sinica B ( IF 14.7 ) Pub Date : 2023-08-19 , DOI: 10.1016/j.apsb.2023.08.012
Dandan Ling _{1,

2} , Xueli Jia ₂ , Ke Wang ₂ , Qiucheng Yan ₂ , Bochuan Yuan ₂ , Lina Du ₂ , Miao Li ₂ , Yiguang Jin _{1,

2}

Affiliation

Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer, although it is limited by the low tumor delivery efficacy of anticancer drugs. Bacterial therapy is emerging for cancer treatment due to its high immune stimulation effect; however, excessively generated immunogenicity will cause serious inflammatory response syndrome. Here, we prepared cancer cell membrane-coated liposomal paclitaxel-loaded bacterial ghosts (LP@BG@CCM) by layer-by-layer encapsulation for the treatment of metastatic lung cancer. The preparation processes were simple, only involving film formation, electroporation, and pore extrusion. LP@BG@CCM owned much higher 4T1 cancer cell toxicity than LP@BG due to its faster fusion with cancer cells. In the 4T1 breast cancer metastatic lung cancer mouse models, the remarkably higher lung targeting of intravenously injected LP@BG@CCM was observed with the almost normalized lung appearance, the reduced lung weight, the clear lung tissue structure, and the enhanced cancer cell apoptosis compared to its precursors. Moreover, several major immune factors were improved after administration of LP@BG@CCM, including the CD4/CD8a T cells in the spleen and the TNF-, IFN-, and IL-4 in the lung. LP@BG@CCM exhibits the optimal synergistic chemo-immunotherapy, which is a promising medication for the treatment of metastatic lung cancer.

中文翻译：

癌细胞膜包被的细菌鬼影可高效输送紫杉醇以对抗转移性肺癌

化疗是治疗转移性肺癌的主要方法之一，尽管它受到抗癌药物肿瘤递送效率低的限制。细菌疗法因其高免疫刺激作用而成为癌症治疗的新兴疗法；然而，过度产生的免疫原性会导致严重的炎症反应综合征。在这里，我们通过层层封装制备了癌细胞膜包被的脂质体紫杉醇细菌幽灵（LP@BG@CCM），用于治疗转移性肺癌。制备过程简单，仅涉及成膜、电穿孔和孔挤出。 LP@BG@CCM 由于与癌细胞融合速度更快，因此比 LP@BG 具有更高的 4T1 癌细胞毒性。在4T1乳腺癌转移性肺癌小鼠模型中，静脉注射LP@BG@CCM的肺靶向性显着提高，肺外观几乎正常化，肺重量减轻，肺组织结构清晰，癌细胞凋亡增强与其前身相比。此外，LP@BG@CCM给药后几个主要免疫因子得到改善，包括脾脏中的CD4/CD8a T细胞和肺中的TNF-、IFN-和IL-4。 LP@BG@CCM表现出最佳的协同化疗免疫疗法，是治疗转移性肺癌的有前途的药物。

更新日期：2023-08-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南