The satisfactory healing of chronic wounds associated with multi-drug resistance (MDR) bacterial infection remains a challenge owing to the persistent inflammation and severe bacterial infection. Herein, we develop an antibacterial anti-oxidative Nb2C MXene hydrogel (FGDN) to alleviate excessive oxidative stress and eradicate bacterial infection for accelerating MRSA-infected wound healing. FGDN hydrogel were prepared by Schiff base reaction between Pluronic F127 aldehyde (FCHO), branched poly (glycerine-amino acid) (GEPL), PDA-modified Nb2C MXene nanosheets (Nb2C@PDA), and 3,3′-dithiodiazine (propionyl hydrazide) (DTPH). FGDN hydrogel exhibited outstanding injectability, conductivity, self-healing, anti-oxidation, tissue adhesion and rapid hemostatic ability. Additionally, FGDN hydrogel could efficiently eliminate excess reactive oxygen species and protect cells from oxidative stress damage in vitro. Meanwhile, FGDN hydrogel could promote cell proliferation with negligible toxicity. Besides, FGDN hydrogel displayed astonishing antibacterial capacity for MDR bacterial MRSA (antibacterial efficiency was about 100% in vitro) without the help of antibiotics. Most importantly, FGDN significantly accelerated MRSA-infected wound healing (wound closure rate: 97.30%) by quickly hemostasis, eradicating bacterial infection, anti-inflammatory, stimulating cell proliferation, angiogenesis, promoting granulation tissue generation, collagen deposition and re-epithelialization. The multifunctional FGDN hydrogel provides an ideal dressing for MRSA-infected wound healing/tissue regeneration.

中文翻译：

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碳化铌掺杂 ROS/温度双响应多功能水凝胶促进 MRSA 感染的伤口愈合


由于持续的炎症和严重的细菌感染，与多药耐药 （MDR） 细菌感染相关的慢性伤口的满意愈合仍然是一个挑战。在此，我们开发了一种抗菌抗氧化 Nb2C MXene 水凝胶 （FGDN），以减轻过度的氧化应激并根除细菌感染，以加速 MRSA 感染的伤口愈合。通过普鲁尼克 F127 醛 （FCHO）、支链聚甘油氨基酸 （GEPL）、PDA 修饰的 Nb2C MXene 纳米片 （Nb2C@PDA） 和 3,3′-二硫代二嗪 （丙酰酰肼） （DTPH） 之间的席夫碱反应制备 FGDN 水凝胶。FGDN 水凝胶表现出优异的注射性、导电性、自愈性、抗氧化性、组织粘附性和快速止血能力。此外，FGDN 水凝胶可以在体外有效消除过量的活性氧并保护细胞免受氧化应激损伤。同时，FGDN 水凝胶可以促进细胞增殖，毒性可以忽略不计。此外，FGDN 水凝胶在没有抗生素帮助的情况下对 MDR 细菌 MRSA 表现出惊人的抗菌能力（体外抗菌效率约为 100%）。最重要的是，FGDN 通过快速止血、根除细菌感染、抗炎、刺激细胞增殖、血管生成、促进肉芽组织生成、胶原蛋白沉积和再上皮化，显著加速 MRSA 感染的伤口愈合 （伤口闭合率：97.30%）。多功能 FGDN 水凝胶为 MRSA 感染的伤口愈合/组织再生提供了理想的敷料。