CD8⁺ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8⁺ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines. Alterations in the glycolysis of CD8⁺ T cells have an important effect on their activation and function, while glycolysis is important for CD8⁺ T cell functional failure and recovery. This paper summarizes the importance of CD8⁺ T cell glycolysis in the immune system. We discuss the link between glycolysis and CD8⁺ T cell activation, differentiation, and proliferation, and the effect of altered glycolysis on CD8⁺ T cell function. In addition, potential molecular targets to enhance and restore the immune function of CD8⁺ T cells by affecting glycolysis and the link between glycolysis and CD8⁺ T cell senescence are summarized. This review provides new insights into the relationship between glycolysis and CD8⁺ T cell function, and proposes novel strategies for immunotherapy by targeting glycolysis.

CD8 ⁺ T细胞是机体适应性免疫反应的重要组成部分。在病毒或细胞内细菌感染时，CD8 ⁺ T细胞迅速激活并分化，通过产生细胞因子发挥免疫功能。^{CD8 +} T细胞糖酵解的改变对其激活和功能具有重要影响，而糖酵解对于CD8 ⁺ T细胞功能衰竭和恢复也很重要。本文总结了CD8 ⁺ T细胞糖酵解在免疫系统中的重要性。^{我们讨论了糖酵解与 CD8 +} T 细胞活化、分化和增殖之间的联系，以及糖酵解改变对 CD8 ⁺ T 细胞功能的影响。此外，还总结了通过影响糖酵解来增强和恢复 CD8 ^{+ T 细胞免疫功能的潜在分子靶标以及糖酵解与 CD8 +} T 细胞衰老之间的联系。^{这篇综述为糖酵解与 CD8 +} T 细胞功能之间的关系提供了新的见解，并提出了针对糖酵解的免疫治疗新策略。