Mechanically-Compliant Bioelectronic Interfaces through Fatigue-Resistant Conducting Polymer Hydrogel Coating,Advanced Materials

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Mechanically-Compliant Bioelectronic Interfaces through Fatigue-Resistant Conducting Polymer Hydrogel Coating
Advanced Materials ( IF 27.4 ) Pub Date : 2023-06-28 , DOI: 10.1002/adma.202304095
Yu Xue ₁ , Xingmei Chen ₁ , Fucheng Wang ₁ , Jingsen Lin ₁ , Ji Liu _{1,

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Affiliation

Because of their distinct electrochemical and mechanical properties, conducting polymer hydrogels have been widely exploited as soft, wet, and conducting coatings for conventional metallic electrodes, providing mechanically compliant interfaces and mitigating foreign body responses. However, the long-term viability of these hydrogel coatings is hindered by concerns regarding fatigue crack propagation and/or delamination caused by repetitive volumetric expansion/shrinkage during long-term electrical interfacing. This study reports a general yet reliable approach to achieving a fatigue-resistant conducting polymer hydrogel coating on conventional metallic bioelectrodes by engineering nanocrystalline domains at the interface between the hydrogel and metallic substrates. It demonstrates the efficacy of this robust, biocompatible, and fatigue-resistant conducting hydrogel coating in cardiac pacing, showcasing its ability to effectively reduce the pacing threshold voltage and enhance the long-term reliability of electric stimulation. This study findings highlight the potential of its approach as a promising design and fabrication strategy for the next generation of seamless bioelectronic interfaces.

中文翻译：

通过抗疲劳导电聚合物水凝胶涂层实现机械兼容的生物电子接口

由于其独特的电化学和机械性能，导电聚合物水凝胶已被广泛用作传统金属电极的柔软、湿润和导电涂层，提供机械顺应性界面并减轻异物反应。然而，这些水凝胶涂层的长期可行性受到长期电接口过程中重复体积膨胀/收缩引起的疲劳裂纹扩展和/或分层的担忧阻碍。这项研究报告了一种通用而可靠的方法，通过在水凝胶和金属基材之间的界面处设计纳米晶域，在传统金属生物电极上实现抗疲劳导电聚合物水凝胶涂层。它展示了这种坚固、生物相容且抗疲劳的导电水凝胶涂层在心脏起搏中的功效，展示了其有效降低起搏阈值电压并增强电刺激的长期可靠性的能力。这项研究结果强调了该方法作为下一代无缝生物电子接口的有前途的设计和制造策略的潜力。

更新日期：2023-06-28

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