A Smart Deoxyribozyme-Programmable Catalytic DNA Circuit for High-Contrast MicroRNA Imaging,Angewandte Chemie International Edition

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A Smart Deoxyribozyme-Programmable Catalytic DNA Circuit for High-Contrast MicroRNA Imaging
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-28 , DOI: 10.1002/anie.202307418
Yuqiu He ₁ , Qing Wang ₁ , Chen Hong ₁ , Ruomeng Li ₁ , Jinhua Shang ₁ , Shanshan Yu ₁ , Xiaoqing Liu ₁ , Fuan Wang _{1,

2}

Affiliation

A dual-responsive DNAzyme-powered entropy-driven reaction circuit (Dz-EDR) was proposed for selective and efficient microRNA imaging with high signal gain and ultralow background. Only under the stimulation of endogenous cancerous mRNA, the DNAzyme amplifier was activated to liberate EDR reactants (fuel strands) for powering the downstream EDR-amplified detection of target microRNA.

中文翻译：

用于高对比度 MicroRNA 成像的智能脱氧核酶可编程催化 DNA 电路

提出了一种双响应 DNAzyme 驱动的熵驱动反应电路 (Dz-EDR)，用于具有高信号增益和超低背景的选择性、高效的 microRNA 成像。只有在内源性癌性 mRNA 的刺激下，DNAzyme 放大器才会被激活，释放 EDR 反应物（燃料链），为下游 EDR 放大的目标 microRNA 检测提供动力。

更新日期：2023-06-28

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