Treatment Patterns and Unmet Needs in the Management of Alopecia Areata: Results of a Physician’s Survey in the Middle East,Dermatology and Therapy

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Treatment Patterns and Unmet Needs in the Management of Alopecia Areata: Results of a Physician’s Survey in the Middle East
Dermatology and Therapy ( IF 3.5 ) Pub Date : 2023-06-24 , DOI: 10.1007/s13555-023-00963-7
Alfred Ammoury ₁ , Rehab Hegazy ₂ , Saad Al Talhab ₃ , Ahmed Ameen ₄ , Nehal Hassan ₅ , Marcelle Ghoubar ₆

Affiliation

Introduction

Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss involving the scalp, face, and/or body. Literature on the prevalence, patient characteristics, management approaches, and challenges faced by patients with AA across the Middle East is limited. Therefore, a greater understanding of the current AA landscape within the region is needed. This cross-sectional study surveyed dermatologists from four countries to assess dermatologists’ perspectives on the prevalence of AA within the Middle East, as well as patient characteristics, unmet needs, and management strategies.

Methods

This blinded, quantitative, observational study surveyed practicing dermatologists in Egypt, Lebanon, Saudi Arabia, and the United Arab Emirates. The survey was conducted between September 2021 and January 2022 and comprised 47 closed-ended, multiple-choice questions as well as Likert scale responses. These questions assessed the characteristics of physicians and the patients in their practices, physicians’ familiarity with treatment, and physicians’ treatment approaches.

Results

The estimated prevalence of AA varied across the region. Across all age groups treated for AA, the majority of patients had AA of mild severity (pediatric: 63%; adolescent: 60%; adult: 54%) and the scalp was reported as the most affected area (65%). Potent topical corticosteroids were the most frequently used treatment for mild to moderate and severe AA (92% and 78%, respectively). There was a lack of awareness of investigative treatments, with only 33% of dermatologists aware of these options. The greatest unmet needs in treating AA included long-term disease control, improved efficacy, faster onset of action, and better safety profiles (62%, 53%, 52%, and 51%, respectively).

Conclusions

This study provided insight into the diagnosis and management of AA in the Middle East. Treatment strategies were similar regardless of the severity of AA. Long-term disease control and improved efficacy and safety profiles were identified as key unmet needs in the treatment of AA.

中文翻译：

斑秃治疗的治疗模式和未满足的需求：中东医生调查的结果

介绍

斑秃 (AA) 是一种自身免疫性疾病，其特征是涉及头皮、面部和/或身体的非疤痕性脱发。关于中东地区 AA 患病率、患者特征、治疗方法和患者面临的挑战的文献有限。因此，需要更深入地了解该地区当前的 AA 格局。这项横断面研究对来自四个国家的皮肤科医生进行了调查，以评估皮肤科医生对中东 AA 患病率以及患者特征、未满足的需求和管理策略的看法。

方法

这项盲法、定量、观察性研究调查了埃及、黎巴嫩、沙特阿拉伯和阿拉伯联合酋长国的执业皮肤科医生。该调查于 2021 年 9 月至 2022 年 1 月期间进行，包含 47 个封闭式多项选择题以及李克特量表回答。这些问题评估了医生和患者在实践中的特征、医生对治疗的熟悉程度以及医生的治疗方法。

结果

AA 的估计患病率在整个地区各不相同。在接受 AA 治疗的所有年龄组中，大多数患者患有轻度严重的 AA（儿童：63%；青少年：60%；成人：54%），据报道头皮是受影响最严重的区域（65%）。强效外用皮质类固醇是轻度至中度和重度 AA 最常用的治疗方法（分别为 92% 和 78%）。人们缺乏对研究性治疗的认识，只有 33% 的皮肤科医生知道这些选择。AA 治疗中最大的未满足需求包括长期疾病控制、提高疗效、更快起效和更好的安全性（分别为 62%、53%、52% 和 51%）。