Novel strategy for acid chlorides formation that do not use carboxylic acids is particularly attractive in chemical synthesis but remains challenging. Herein, we reported the development of a highly effective Pd-catalyzed hydrochlorocarbonylation of alkenes with CO for the formation of alkyl acid chlorides. Chlorosilane and AcOH were found as a mild HCl source for the reaction. The reaction shows broad substrate scope and produces both branched and linear alkyl acid chlorides in good to high yields upon different ligands and solvents. Cooperating with follow-up acylation reactions, the Pd-catalyzed hydrochlorocarbonylation offers a complementary platform for the synthesis of diverse carbonyl compounds from alkenes. Mechanistic investigations suggested that the reaction proceeded though a palladium hydride pathway, and CO prompted reductive elimination of the acyl-Pd-Cl intermediate.

不使用羧酸形成酰氯的新策略在化学合成中特别有吸引力，但仍然具有挑战性。在此，我们报道了一种高效的 Pd 催化的烯烃与 CO 的氢氯羰基化反应，用于形成烷基酰氯。发现氯硅烷和 AcOH 作为反应的温和 HCl 源。该反应显示出广泛的底物范围，并在不同的配体和溶剂下以良好到高产率产生支链和直链烷基酰氯。Pd 催化的氢氯羰基化与后续酰化反应相配合，为从烯烃合成多种羰基化合物提供了一个互补平台。机理研究表明反应通过氢化钯途径进行，