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Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration
Small ( IF 13.0 ) Pub Date : 2023-04-28 , DOI: 10.1002/smll.202301996 Yafei Han 1 , Liehu Cao 2 , Guangfeng Li 3 , Fengjin Zhou 4 , Long Bai 1 , Jiacan Su 1
Small ( IF 13.0 ) Pub Date : 2023-04-28 , DOI: 10.1002/smll.202301996 Yafei Han 1 , Liehu Cao 2 , Guangfeng Li 3 , Fengjin Zhou 4 , Long Bai 1 , Jiacan Su 1
Affiliation
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The effective regeneration of weight-bearing bone defects and critical-sized cartilage defects remains a significant clinical challenge. Traditional treatments such as autologous and allograft bone grafting have not been successful in achieving the desired outcomes, necessitating the need for innovative therapeutic approaches. Nucleic acids have attracted significant attention due to their ability to be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of nucleic acid nanotechnology offer numerous opportunities for in-cell and in vivo applications, and hold great promise for advancing the field of biomaterials. In this review, the current abilities of nucleic acid nanotechnology to be applied in bone and cartilage regeneration are summarized and insights into the challenges and future directions for the development of this technology are provided.
中文翻译：
利用核酸纳米技术进行骨/软骨再生
承重骨缺损和临界尺寸软骨缺损的有效再生仍然是一个重大的临床挑战。自体骨和同种异体骨移植等传统治疗方法尚未成功实现预期结果，因此需要创新的治疗方法。核酸因其能够被设计形成离散结构并被编程以在纳米尺度上执行特定功能而引起了极大的关注。核酸纳米技术的优势为细胞内和体内应用提供了众多机会，并为生物材料领域的发展带来了巨大希望。本文总结了核酸纳米技术目前在骨和软骨再生中应用的能力，并对该技术的发展挑战和未来方向进行了深入探讨。
更新日期：2023-04-28
中文翻译：
利用核酸纳米技术进行骨/软骨再生
承重骨缺损和临界尺寸软骨缺损的有效再生仍然是一个重大的临床挑战。自体骨和同种异体骨移植等传统治疗方法尚未成功实现预期结果，因此需要创新的治疗方法。核酸因其能够被设计形成离散结构并被编程以在纳米尺度上执行特定功能而引起了极大的关注。核酸纳米技术的优势为细胞内和体内应用提供了众多机会，并为生物材料领域的发展带来了巨大希望。本文总结了核酸纳米技术目前在骨和软骨再生中应用的能力，并对该技术的发展挑战和未来方向进行了深入探讨。
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